Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver
Hepatic fibrosis represents the liver response to chronic injury and can lead to cirrhosis. Here the authors show that mucosal-associated invariant T cells mediate chronic inflammation and fibrogenesis in the liver by inducing a proinflammatory phenotype in macrophages and myofibroblasts and prolife...
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Nature Portfolio
2018
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oai:doaj.org-article:68dba654aed943aea66393450ba3bbd92021-12-02T17:31:59ZMucosal-associated invariant T cells are a profibrogenic immune cell population in the liver10.1038/s41467-018-04450-y2041-1723https://doaj.org/article/68dba654aed943aea66393450ba3bbd92018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04450-yhttps://doaj.org/toc/2041-1723Hepatic fibrosis represents the liver response to chronic injury and can lead to cirrhosis. Here the authors show that mucosal-associated invariant T cells mediate chronic inflammation and fibrogenesis in the liver by inducing a proinflammatory phenotype in macrophages and myofibroblasts and proliferation of the latter.Pushpa HegdeEmmanuel WeissValérie ParadisJinghong WanMorgane MabireSukriti SukritiPierre-Emmanuel RautouMiguel AlbuquerqueOlivia PicqAbhishak Chandra GuptaGladys FerrereHélène GilgenkrantzBadr KiafAmine ToubalLucie BeaudoinPhilippe LettéronRichard MoreauAgnès LehuenSophie LotersztajnNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Pushpa Hegde Emmanuel Weiss Valérie Paradis Jinghong Wan Morgane Mabire Sukriti Sukriti Pierre-Emmanuel Rautou Miguel Albuquerque Olivia Picq Abhishak Chandra Gupta Gladys Ferrere Hélène Gilgenkrantz Badr Kiaf Amine Toubal Lucie Beaudoin Philippe Lettéron Richard Moreau Agnès Lehuen Sophie Lotersztajn Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver |
| description |
Hepatic fibrosis represents the liver response to chronic injury and can lead to cirrhosis. Here the authors show that mucosal-associated invariant T cells mediate chronic inflammation and fibrogenesis in the liver by inducing a proinflammatory phenotype in macrophages and myofibroblasts and proliferation of the latter. |
| format |
article |
| author |
Pushpa Hegde Emmanuel Weiss Valérie Paradis Jinghong Wan Morgane Mabire Sukriti Sukriti Pierre-Emmanuel Rautou Miguel Albuquerque Olivia Picq Abhishak Chandra Gupta Gladys Ferrere Hélène Gilgenkrantz Badr Kiaf Amine Toubal Lucie Beaudoin Philippe Lettéron Richard Moreau Agnès Lehuen Sophie Lotersztajn |
| author_facet |
Pushpa Hegde Emmanuel Weiss Valérie Paradis Jinghong Wan Morgane Mabire Sukriti Sukriti Pierre-Emmanuel Rautou Miguel Albuquerque Olivia Picq Abhishak Chandra Gupta Gladys Ferrere Hélène Gilgenkrantz Badr Kiaf Amine Toubal Lucie Beaudoin Philippe Lettéron Richard Moreau Agnès Lehuen Sophie Lotersztajn |
| author_sort |
Pushpa Hegde |
| title |
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver |
| title_short |
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver |
| title_full |
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver |
| title_fullStr |
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver |
| title_full_unstemmed |
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver |
| title_sort |
mucosal-associated invariant t cells are a profibrogenic immune cell population in the liver |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/68dba654aed943aea66393450ba3bbd9 |
| work_keys_str_mv |
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| _version_ |
1718380434019057664 |