Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan

The objective was to investigate different comorbidities developed in normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG) patients. This was a case-control study, with 1489 people in the NTG group and 5120 people in the POAG group. Patient data were obtained from the Longitudinal He...

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Autores principales:	Wei-Yang Lu, Ci-Wen Luo, Shyan-Tarng Chen, Yu-Hsiang Kuan, Shun-Fa Yang, Han-Yin Sun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	normal tension glaucoma primary open-angle glaucoma comorbidities Medicine R
Acceso en línea:	https://doaj.org/article/68dd3340b6b0446a9a0ae43d58356553
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spelling	oai:doaj.org-article:68dd3340b6b0446a9a0ae43d583565532021-11-25T17:45:21ZComparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan10.3390/healthcare91115092227-9032https://doaj.org/article/68dd3340b6b0446a9a0ae43d583565532021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1509https://doaj.org/toc/2227-9032The objective was to investigate different comorbidities developed in normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG) patients. This was a case-control study, with 1489 people in the NTG group and 5120 people in the POAG group. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008–2013 period. The chi-square test was used to compare categorical variables, such as gender, income and urbanisation level, between NTG and POAG patients, and the two-tailed <i>t</i> test was used to compare continuity between the two groups. We use a multivariate logic regression model to assess the risk of each participant. The results are expressed in terms of odds ratio (OR) and 95% confidence intervals (CI). Patients with NTG had significantly higher proportions of hypotension (adjusted OR, 1.984; 95% CI, 1.128–3.490), sleep disturbances (adjusted OR, 1.323; 95% CI, 1.146–1.528), peptic ulcers (adjusted OR, 1.383; 95% CI, 1.188–1.609) and allergic rhinitis (adjusted OR, 1.484; 95% CI, 1.290–1.707) than those with POAG. Conversely, arterial hypertension (adjusted OR, 0.767; 95% CI, 0.660–0.893), diabetes (adjusted OR, 0.850; 95% CI, 0.728–0.993) and atopic dermatitis (adjusted OR, 0.869; 95% CI, 0.763–0.990) had a lower risk in the NTG group than in the POAG group. We found that comorbidities such a hypotension, sleep disturbances and peptic ulcer and allergic rhinitis are more highly associated to NTG than POAG.Wei-Yang LuCi-Wen LuoShyan-Tarng ChenYu-Hsiang KuanShun-Fa YangHan-Yin SunMDPI AGarticlenormal tension glaucomaprimary open-angle glaucomacomorbiditiesMedicineRENHealthcare, Vol 9, Iss 1509, p 1509 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	normal tension glaucoma primary open-angle glaucoma comorbidities Medicine R
spellingShingle	normal tension glaucoma primary open-angle glaucoma comorbidities Medicine R Wei-Yang Lu Ci-Wen Luo Shyan-Tarng Chen Yu-Hsiang Kuan Shun-Fa Yang Han-Yin Sun Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan
description	The objective was to investigate different comorbidities developed in normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG) patients. This was a case-control study, with 1489 people in the NTG group and 5120 people in the POAG group. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008–2013 period. The chi-square test was used to compare categorical variables, such as gender, income and urbanisation level, between NTG and POAG patients, and the two-tailed <i>t</i> test was used to compare continuity between the two groups. We use a multivariate logic regression model to assess the risk of each participant. The results are expressed in terms of odds ratio (OR) and 95% confidence intervals (CI). Patients with NTG had significantly higher proportions of hypotension (adjusted OR, 1.984; 95% CI, 1.128–3.490), sleep disturbances (adjusted OR, 1.323; 95% CI, 1.146–1.528), peptic ulcers (adjusted OR, 1.383; 95% CI, 1.188–1.609) and allergic rhinitis (adjusted OR, 1.484; 95% CI, 1.290–1.707) than those with POAG. Conversely, arterial hypertension (adjusted OR, 0.767; 95% CI, 0.660–0.893), diabetes (adjusted OR, 0.850; 95% CI, 0.728–0.993) and atopic dermatitis (adjusted OR, 0.869; 95% CI, 0.763–0.990) had a lower risk in the NTG group than in the POAG group. We found that comorbidities such a hypotension, sleep disturbances and peptic ulcer and allergic rhinitis are more highly associated to NTG than POAG.
format	article
author	Wei-Yang Lu Ci-Wen Luo Shyan-Tarng Chen Yu-Hsiang Kuan Shun-Fa Yang Han-Yin Sun
author_facet	Wei-Yang Lu Ci-Wen Luo Shyan-Tarng Chen Yu-Hsiang Kuan Shun-Fa Yang Han-Yin Sun
author_sort	Wei-Yang Lu
title	Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan
title_short	Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan
title_full	Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan
title_fullStr	Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan
title_full_unstemmed	Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan
title_sort	comparison of medical comorbidity between patients with normal-tension glaucoma and primary open-angle glaucoma: a population-based study in taiwan
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/68dd3340b6b0446a9a0ae43d58356553
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Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan

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