Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC

Abstract In the eighth TNM staging system proposal for NSCLC recently, classification of N stage is based on anatomical position of positive lymph nodes. We aimed to expand the sample volume to identify the value of positive lymph node number or ratio in prognosis and predictive effect for postopera...

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Autores principales:	Nan Ding, ZhaoFei Pang, Xiangwei Zhang, Cuicui Huang, Yufan Yang, Qi Liu, Jiajun Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68e4e2c7ff9549f19cf9ecdd5dd12468
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spelling	oai:doaj.org-article:68e4e2c7ff9549f19cf9ecdd5dd124682021-12-02T15:06:09ZPrognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC10.1038/s41598-017-00619-52045-2322https://doaj.org/article/68e4e2c7ff9549f19cf9ecdd5dd124682017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00619-5https://doaj.org/toc/2045-2322Abstract In the eighth TNM staging system proposal for NSCLC recently, classification of N stage is based on anatomical position of positive lymph nodes. We aimed to expand the sample volume to identify the value of positive lymph node number or ratio in prognosis and predictive effect for postoperative radiation. Clinicopathological characters of 109026 NSCLC patients were collected from the SEER Database. Kaplan-Meier curves and cox regression methods were used for survival analysis. Compared with positive lymph node number equal to 0, 1–3 and >3 groups were independent prognostic factors (1–3: HR 2.856, p < 0.001; >3: HR 3.358, p < 0.001), so as the 0–50% and >50% positive lymph node ratio groups (0–50%: HR 2.124, p < 0.001; >50%: HR 3.358, p < 0.001). And in the groups of N2&positive lymph node number ≥4 and N2&positive lymph node ratio >50%, postoperative radiation related to positive prognosis of NSCLC patients. In conclusion, positive lymph node number or ratio was associated with survival as an independent indicator in NSCLC. They also had predictive effects for postoperative radiation, while N nodal stage not.Nan DingZhaoFei PangXiangwei ZhangCuicui HuangYufan YangQi LiuJiajun DuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nan Ding ZhaoFei Pang Xiangwei Zhang Cuicui Huang Yufan Yang Qi Liu Jiajun Du Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC
description	Abstract In the eighth TNM staging system proposal for NSCLC recently, classification of N stage is based on anatomical position of positive lymph nodes. We aimed to expand the sample volume to identify the value of positive lymph node number or ratio in prognosis and predictive effect for postoperative radiation. Clinicopathological characters of 109026 NSCLC patients were collected from the SEER Database. Kaplan-Meier curves and cox regression methods were used for survival analysis. Compared with positive lymph node number equal to 0, 1–3 and >3 groups were independent prognostic factors (1–3: HR 2.856, p < 0.001; >3: HR 3.358, p < 0.001), so as the 0–50% and >50% positive lymph node ratio groups (0–50%: HR 2.124, p < 0.001; >50%: HR 3.358, p < 0.001). And in the groups of N2&positive lymph node number ≥4 and N2&positive lymph node ratio >50%, postoperative radiation related to positive prognosis of NSCLC patients. In conclusion, positive lymph node number or ratio was associated with survival as an independent indicator in NSCLC. They also had predictive effects for postoperative radiation, while N nodal stage not.
format	article
author	Nan Ding ZhaoFei Pang Xiangwei Zhang Cuicui Huang Yufan Yang Qi Liu Jiajun Du
author_facet	Nan Ding ZhaoFei Pang Xiangwei Zhang Cuicui Huang Yufan Yang Qi Liu Jiajun Du
author_sort	Nan Ding
title	Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC
title_short	Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC
title_full	Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC
title_fullStr	Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC
title_full_unstemmed	Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC
title_sort	prognostic and predictive effects of positive lymph node number or ratio in nsclc
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68e4e2c7ff9549f19cf9ecdd5dd12468
work_keys_str_mv	AT nanding prognosticandpredictiveeffectsofpositivelymphnodenumberorratioinnsclc AT zhaofeipang prognosticandpredictiveeffectsofpositivelymphnodenumberorratioinnsclc AT xiangweizhang prognosticandpredictiveeffectsofpositivelymphnodenumberorratioinnsclc AT cuicuihuang prognosticandpredictiveeffectsofpositivelymphnodenumberorratioinnsclc AT yufanyang prognosticandpredictiveeffectsofpositivelymphnodenumberorratioinnsclc AT qiliu prognosticandpredictiveeffectsofpositivelymphnodenumberorratioinnsclc AT jiajundu prognosticandpredictiveeffectsofpositivelymphnodenumberorratioinnsclc
_version_	1718388587506958336

Prognostic and Predictive Effects of Positive Lymph Node Number or Ratio in NSCLC

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