Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)

Abstract Fluorescent light (FL) has been shown to induce a cellular immune and inflammatory response that is conserved over 450 MY of evolutionary divergence and among vertebrates having drastically different lifestyles such as Mus musculus, Danio rerio, Oryzias latipes and Xiphophorus maculatus. Th...

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Autores principales:	Mikki Boswell, William Boswell, Yuan Lu, Markita Savage, Ronald B. Walter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68e59f124bf7418993115b724e229d33
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spelling	oai:doaj.org-article:68e59f124bf7418993115b724e229d332021-12-02T10:59:52ZDeconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)10.1038/s41598-020-59502-52045-2322https://doaj.org/article/68e59f124bf7418993115b724e229d332020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-59502-5https://doaj.org/toc/2045-2322Abstract Fluorescent light (FL) has been shown to induce a cellular immune and inflammatory response that is conserved over 450 MY of evolutionary divergence and among vertebrates having drastically different lifestyles such as Mus musculus, Danio rerio, Oryzias latipes and Xiphophorus maculatus. This surprising finding of an inflammation and immune response to FL not only holds for direct light receiving organs (skin) but is also observed within internal organs (brain and liver). Light responsive genetic circuitry initiated by the IL1B regulator induces a highly conserved acute phase response in each organ assessed for all of biological models surveyed to date; however, the specific light wavelengths triggering this response have yet to be determined so investigation of mechanisms and/or light specific molecule(s) leading to this response are difficult to assess. To understand how specific light wavelengths are received in both external and internal organs, zebrafish were exposed to specific 50 nm light wavebands spanning the visible spectrum from 300–600 nm and the genetic responses to each waveband exposure were assessed. Surprisingly, the induced cellular stress response previously observed following FL exposure is not triggered by the lower “damaging” wavelengths of light (UVB and UVA from 300–400 nm) but instead is maximally induced by higher wavelengths ranging from 450–500 nm in skin to 500–600 nm in both brain and liver).Mikki BoswellWilliam BoswellYuan LuMarkita SavageRonald B. WalterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mikki Boswell William Boswell Yuan Lu Markita Savage Ronald B. Walter Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)
description	Abstract Fluorescent light (FL) has been shown to induce a cellular immune and inflammatory response that is conserved over 450 MY of evolutionary divergence and among vertebrates having drastically different lifestyles such as Mus musculus, Danio rerio, Oryzias latipes and Xiphophorus maculatus. This surprising finding of an inflammation and immune response to FL not only holds for direct light receiving organs (skin) but is also observed within internal organs (brain and liver). Light responsive genetic circuitry initiated by the IL1B regulator induces a highly conserved acute phase response in each organ assessed for all of biological models surveyed to date; however, the specific light wavelengths triggering this response have yet to be determined so investigation of mechanisms and/or light specific molecule(s) leading to this response are difficult to assess. To understand how specific light wavelengths are received in both external and internal organs, zebrafish were exposed to specific 50 nm light wavebands spanning the visible spectrum from 300–600 nm and the genetic responses to each waveband exposure were assessed. Surprisingly, the induced cellular stress response previously observed following FL exposure is not triggered by the lower “damaging” wavelengths of light (UVB and UVA from 300–400 nm) but instead is maximally induced by higher wavelengths ranging from 450–500 nm in skin to 500–600 nm in both brain and liver).
format	article
author	Mikki Boswell William Boswell Yuan Lu Markita Savage Ronald B. Walter
author_facet	Mikki Boswell William Boswell Yuan Lu Markita Savage Ronald B. Walter
author_sort	Mikki Boswell
title	Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)
title_short	Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)
title_full	Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)
title_fullStr	Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)
title_full_unstemmed	Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)
title_sort	deconvoluting wavelengths leading to fluorescent light induced inflammation and cellular stress in zebrafish (danio rerio)
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/68e59f124bf7418993115b724e229d33
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Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio)

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