Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study

Jennifer S Fogt,1 Nick Fogt,1 P Ewen King-Smith,1 Haixia Liu,2 Joseph T Barr1 1Ohio State University College of Optometry, Columbus, OH, USA; 2Allergan Plc, Irvine, CA, USACorrespondence: Jennifer S FogtThe Ohio State University College of Optometry, 338 West 10th Avenue, Columbus, OH 43210-1280, US...

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Autores principales:	Fogt JS, Fogt N, King-Smith PE, Liu H, Barr JT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	dry eye artificial tears ophthalmic solution omega-3 fatty acids survey tear lipid layer Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/68e60b67d37f40c78d4dbfd375ea0c74
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spelling	oai:doaj.org-article:68e60b67d37f40c78d4dbfd375ea0c742021-12-02T09:15:25ZChanges in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study1177-5483https://doaj.org/article/68e60b67d37f40c78d4dbfd375ea0c742019-12-01T00:00:00Zhttps://www.dovepress.com/changes-in-tear-lipid-layer-thickness-and-symptoms-following-the-use-o-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Jennifer S Fogt,1 Nick Fogt,1 P Ewen King-Smith,1 Haixia Liu,2 Joseph T Barr1 1Ohio State University College of Optometry, Columbus, OH, USA; 2Allergan Plc, Irvine, CA, USACorrespondence: Jennifer S FogtThe Ohio State University College of Optometry, 338 West 10th Avenue, Columbus, OH 43210-1280, USATel +1 614-292-0882Email Fogt.78@osu.eduPurpose: To determine if an eye drop containing omega-3 fatty acids (Refresh Optive MEGA-3®, Allergan plc, Dublin, Ireland) increases the lipid layer thickness (LLT) of the tear film versus a non-emollient eye drop (Refresh Optive, Allergan plc).Methods: Patients (≥30 years) with baseline LLT ≤75 nm completed the Current Symptoms Survey (CSS – a visual analog survey of dry eye symptoms), and LLT was measured pre- and post-instillation (15 and 60 mins) of their randomly assigned treatment. After washout, patients were tested with the other treatment. Primary endpoint: change in LLT from baseline. Secondary endpoint: CSS results.Results: Of 21 patients enrolled, 19 completed the study. With the omega-3–containing eye drop, the mean (standard deviation) LLT increase from baseline at 15 mins was statistically significant in the overall field (8.8 [11.5] nm; P<0.001), and in each individual zone (superior, central, and inferior). At 1 hr, the LLT change from baseline was statistically significant overall (4.4 [9.7] nm; P<0.02) and in the inferior and central zones. With the aqueous eye drop, LLT change from baseline was only significant at 15 mins in the inferior field. The CSS analysis revealed a ≥8.68-unit decrease in mean average dryness score from baseline at 15 and 60 mins post-instillation of the lipid-based treatment (P≤0.03).Conclusion: The eye drop containing omega-3 fatty acids increased LLT at 15 mins, maintaining it at 1 hr post-instillation. Dryness symptoms also improved and maintained improved levels 1 hr after instillation, indicating that the product may benefit symptomatic patients with evaporative dry eye.Keywords: dry eye, artificial tears, ophthalmic solution, omega-3 fatty acids, survey, tear lipid layerFogt JSFogt NKing-Smith PELiu HBarr JTDove Medical Pressarticledry eyeartificial tearsophthalmic solutionomega-3 fatty acidssurveytear lipid layerOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2553-2561 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye artificial tears ophthalmic solution omega-3 fatty acids survey tear lipid layer Ophthalmology RE1-994
spellingShingle	dry eye artificial tears ophthalmic solution omega-3 fatty acids survey tear lipid layer Ophthalmology RE1-994 Fogt JS Fogt N King-Smith PE Liu H Barr JT Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study
description	Jennifer S Fogt,1 Nick Fogt,1 P Ewen King-Smith,1 Haixia Liu,2 Joseph T Barr1 1Ohio State University College of Optometry, Columbus, OH, USA; 2Allergan Plc, Irvine, CA, USACorrespondence: Jennifer S FogtThe Ohio State University College of Optometry, 338 West 10th Avenue, Columbus, OH 43210-1280, USATel +1 614-292-0882Email Fogt.78@osu.eduPurpose: To determine if an eye drop containing omega-3 fatty acids (Refresh Optive MEGA-3®, Allergan plc, Dublin, Ireland) increases the lipid layer thickness (LLT) of the tear film versus a non-emollient eye drop (Refresh Optive, Allergan plc).Methods: Patients (≥30 years) with baseline LLT ≤75 nm completed the Current Symptoms Survey (CSS – a visual analog survey of dry eye symptoms), and LLT was measured pre- and post-instillation (15 and 60 mins) of their randomly assigned treatment. After washout, patients were tested with the other treatment. Primary endpoint: change in LLT from baseline. Secondary endpoint: CSS results.Results: Of 21 patients enrolled, 19 completed the study. With the omega-3–containing eye drop, the mean (standard deviation) LLT increase from baseline at 15 mins was statistically significant in the overall field (8.8 [11.5] nm; P<0.001), and in each individual zone (superior, central, and inferior). At 1 hr, the LLT change from baseline was statistically significant overall (4.4 [9.7] nm; P<0.02) and in the inferior and central zones. With the aqueous eye drop, LLT change from baseline was only significant at 15 mins in the inferior field. The CSS analysis revealed a ≥8.68-unit decrease in mean average dryness score from baseline at 15 and 60 mins post-instillation of the lipid-based treatment (P≤0.03).Conclusion: The eye drop containing omega-3 fatty acids increased LLT at 15 mins, maintaining it at 1 hr post-instillation. Dryness symptoms also improved and maintained improved levels 1 hr after instillation, indicating that the product may benefit symptomatic patients with evaporative dry eye.Keywords: dry eye, artificial tears, ophthalmic solution, omega-3 fatty acids, survey, tear lipid layer
format	article
author	Fogt JS Fogt N King-Smith PE Liu H Barr JT
author_facet	Fogt JS Fogt N King-Smith PE Liu H Barr JT
author_sort	Fogt JS
title	Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study
title_short	Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study
title_full	Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study
title_fullStr	Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study
title_full_unstemmed	Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study
title_sort	changes in tear lipid layer thickness and symptoms following the use of artificial tears with and without omega-3 fatty acids: arandomized, double-masked, crossover study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/68e60b67d37f40c78d4dbfd375ea0c74
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Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: ARandomized, Double-Masked, Crossover Study

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