The Growing Relevance of Immunoregulation in Pediatric Brain Tumors

Pediatric brain tumors are genetically heterogeneous solid neoplasms. With a prevailing poor prognosis and widespread resistance to conventional multimodal therapy, these aggressive tumors are the leading cause of childhood cancer-related deaths worldwide. Advancement in molecular research revealed...

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Autores principales:	Viktoria Melcher, Kornelius Kerl
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pediatric brain tumors embryonal brain tumors atypical teratoid/rhabdoid tumor ependymoma high-grade glioma low-grade glioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/68e940d503584f9384e8c10427a4eeca
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spelling	oai:doaj.org-article:68e940d503584f9384e8c10427a4eeca2021-11-25T17:01:09ZThe Growing Relevance of Immunoregulation in Pediatric Brain Tumors10.3390/cancers132256012072-6694https://doaj.org/article/68e940d503584f9384e8c10427a4eeca2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5601https://doaj.org/toc/2072-6694Pediatric brain tumors are genetically heterogeneous solid neoplasms. With a prevailing poor prognosis and widespread resistance to conventional multimodal therapy, these aggressive tumors are the leading cause of childhood cancer-related deaths worldwide. Advancement in molecular research revealed their unique genetic and epigenetic characteristics and paved the way for more defined prognostication and targeted therapeutic approaches. Furthermore, uncovering the intratumoral metrics on a single-cell level placed non-malignant cell populations such as innate immune cells into the context of tumor manifestation and progression. Targeting immune cells in pediatric brain tumors entails unique challenges but promising opportunities to improve outcome. Herein, we outline the current understanding of the role of the immune regulation in pediatric brain tumors.Viktoria MelcherKornelius KerlMDPI AGarticlepediatric brain tumorsembryonal brain tumorsatypical teratoid/rhabdoid tumorependymomahigh-grade gliomalow-grade gliomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5601, p 5601 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pediatric brain tumors embryonal brain tumors atypical teratoid/rhabdoid tumor ependymoma high-grade glioma low-grade glioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	pediatric brain tumors embryonal brain tumors atypical teratoid/rhabdoid tumor ependymoma high-grade glioma low-grade glioma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Viktoria Melcher Kornelius Kerl The Growing Relevance of Immunoregulation in Pediatric Brain Tumors
description	Pediatric brain tumors are genetically heterogeneous solid neoplasms. With a prevailing poor prognosis and widespread resistance to conventional multimodal therapy, these aggressive tumors are the leading cause of childhood cancer-related deaths worldwide. Advancement in molecular research revealed their unique genetic and epigenetic characteristics and paved the way for more defined prognostication and targeted therapeutic approaches. Furthermore, uncovering the intratumoral metrics on a single-cell level placed non-malignant cell populations such as innate immune cells into the context of tumor manifestation and progression. Targeting immune cells in pediatric brain tumors entails unique challenges but promising opportunities to improve outcome. Herein, we outline the current understanding of the role of the immune regulation in pediatric brain tumors.
format	article
author	Viktoria Melcher Kornelius Kerl
author_facet	Viktoria Melcher Kornelius Kerl
author_sort	Viktoria Melcher
title	The Growing Relevance of Immunoregulation in Pediatric Brain Tumors
title_short	The Growing Relevance of Immunoregulation in Pediatric Brain Tumors
title_full	The Growing Relevance of Immunoregulation in Pediatric Brain Tumors
title_fullStr	The Growing Relevance of Immunoregulation in Pediatric Brain Tumors
title_full_unstemmed	The Growing Relevance of Immunoregulation in Pediatric Brain Tumors
title_sort	growing relevance of immunoregulation in pediatric brain tumors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/68e940d503584f9384e8c10427a4eeca
work_keys_str_mv	AT viktoriamelcher thegrowingrelevanceofimmunoregulationinpediatricbraintumors AT korneliuskerl thegrowingrelevanceofimmunoregulationinpediatricbraintumors AT viktoriamelcher growingrelevanceofimmunoregulationinpediatricbraintumors AT korneliuskerl growingrelevanceofimmunoregulationinpediatricbraintumors
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The Growing Relevance of Immunoregulation in Pediatric Brain Tumors

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