Dentate granule cells encode auditory decisions after reinforcement learning in rats

Abstract Auditory-cued goal-oriented behaviors requires the participation of cortical and subcortical brain areas, but how neural circuits associate sensory-based decisions with goal locations through learning remains poorly understood. The hippocampus is critical for spatial coding, suggesting its...

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Autores principales:	Jia Shen, Pan-Tong Yao, Shaoyu Ge, Qiaojie Xiong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68eae5e86e724bfb8b6ce59f7e103502
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id	oai:doaj.org-article:68eae5e86e724bfb8b6ce59f7e103502
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spelling	oai:doaj.org-article:68eae5e86e724bfb8b6ce59f7e1035022021-12-02T16:14:09ZDentate granule cells encode auditory decisions after reinforcement learning in rats10.1038/s41598-021-93721-82045-2322https://doaj.org/article/68eae5e86e724bfb8b6ce59f7e1035022021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93721-8https://doaj.org/toc/2045-2322Abstract Auditory-cued goal-oriented behaviors requires the participation of cortical and subcortical brain areas, but how neural circuits associate sensory-based decisions with goal locations through learning remains poorly understood. The hippocampus is critical for spatial coding, suggesting its possible involvement in transforming sensory inputs to the goal-oriented decisions. Here, we developed an auditory discrimination task in which rats learned to navigate to goal locations based on the frequencies of auditory stimuli. Using in vivo calcium imaging in freely behaving rats over the course of learning, we found that dentate granule cells became more active, spatially tuned, and responsive to task-related variables as learning progressed. Furthermore, only after task learning, the activity of dentate granule cell ensembles represented the navigation path and predicts auditory decisions as early as when rats began to approach the goals. Finally, chemogenetic silencing of dentate gyrus suppressed task learning. Our results demonstrate that dentate granule cells gain task-relevant firing pattern through reinforcement learning and could be a potential link of sensory decisions to spatial navigation.Jia ShenPan-Tong YaoShaoyu GeQiaojie XiongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jia Shen Pan-Tong Yao Shaoyu Ge Qiaojie Xiong Dentate granule cells encode auditory decisions after reinforcement learning in rats
description	Abstract Auditory-cued goal-oriented behaviors requires the participation of cortical and subcortical brain areas, but how neural circuits associate sensory-based decisions with goal locations through learning remains poorly understood. The hippocampus is critical for spatial coding, suggesting its possible involvement in transforming sensory inputs to the goal-oriented decisions. Here, we developed an auditory discrimination task in which rats learned to navigate to goal locations based on the frequencies of auditory stimuli. Using in vivo calcium imaging in freely behaving rats over the course of learning, we found that dentate granule cells became more active, spatially tuned, and responsive to task-related variables as learning progressed. Furthermore, only after task learning, the activity of dentate granule cell ensembles represented the navigation path and predicts auditory decisions as early as when rats began to approach the goals. Finally, chemogenetic silencing of dentate gyrus suppressed task learning. Our results demonstrate that dentate granule cells gain task-relevant firing pattern through reinforcement learning and could be a potential link of sensory decisions to spatial navigation.
format	article
author	Jia Shen Pan-Tong Yao Shaoyu Ge Qiaojie Xiong
author_facet	Jia Shen Pan-Tong Yao Shaoyu Ge Qiaojie Xiong
author_sort	Jia Shen
title	Dentate granule cells encode auditory decisions after reinforcement learning in rats
title_short	Dentate granule cells encode auditory decisions after reinforcement learning in rats
title_full	Dentate granule cells encode auditory decisions after reinforcement learning in rats
title_fullStr	Dentate granule cells encode auditory decisions after reinforcement learning in rats
title_full_unstemmed	Dentate granule cells encode auditory decisions after reinforcement learning in rats
title_sort	dentate granule cells encode auditory decisions after reinforcement learning in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/68eae5e86e724bfb8b6ce59f7e103502
work_keys_str_mv	AT jiashen dentategranulecellsencodeauditorydecisionsafterreinforcementlearninginrats AT pantongyao dentategranulecellsencodeauditorydecisionsafterreinforcementlearninginrats AT shaoyuge dentategranulecellsencodeauditorydecisionsafterreinforcementlearninginrats AT qiaojiexiong dentategranulecellsencodeauditorydecisionsafterreinforcementlearninginrats
_version_	1718384353672691712

Dentate granule cells encode auditory decisions after reinforcement learning in rats

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