Structural basis for the ARF GAP activity and specificity of the C9orf72 complex

C9orf72:SMCR8:WDR41 complex has been reported to have GAP activity for both ARF family proteins and the RAB proteins RAB8A and RAB11A. Here the authors provide structural and biochemical evidence for a specific function of the C9orf72 complex as an ARF GAP, and a structural framework for the GAP act...

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Autores principales:	Ming-Yuan Su, Simon A. Fromm, Jonathan Remis, Daniel B. Toso, James H. Hurley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68ecccfd058a41458fb45ddd911e60ed
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spelling	oai:doaj.org-article:68ecccfd058a41458fb45ddd911e60ed2021-12-02T17:24:21ZStructural basis for the ARF GAP activity and specificity of the C9orf72 complex10.1038/s41467-021-24081-02041-1723https://doaj.org/article/68ecccfd058a41458fb45ddd911e60ed2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24081-0https://doaj.org/toc/2041-1723C9orf72:SMCR8:WDR41 complex has been reported to have GAP activity for both ARF family proteins and the RAB proteins RAB8A and RAB11A. Here the authors provide structural and biochemical evidence for a specific function of the C9orf72 complex as an ARF GAP, and a structural framework for the GAP activity of the longin-containing GAP family.Ming-Yuan SuSimon A. FrommJonathan RemisDaniel B. TosoJames H. HurleyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming-Yuan Su Simon A. Fromm Jonathan Remis Daniel B. Toso James H. Hurley Structural basis for the ARF GAP activity and specificity of the C9orf72 complex
description	C9orf72:SMCR8:WDR41 complex has been reported to have GAP activity for both ARF family proteins and the RAB proteins RAB8A and RAB11A. Here the authors provide structural and biochemical evidence for a specific function of the C9orf72 complex as an ARF GAP, and a structural framework for the GAP activity of the longin-containing GAP family.
format	article
author	Ming-Yuan Su Simon A. Fromm Jonathan Remis Daniel B. Toso James H. Hurley
author_facet	Ming-Yuan Su Simon A. Fromm Jonathan Remis Daniel B. Toso James H. Hurley
author_sort	Ming-Yuan Su
title	Structural basis for the ARF GAP activity and specificity of the C9orf72 complex
title_short	Structural basis for the ARF GAP activity and specificity of the C9orf72 complex
title_full	Structural basis for the ARF GAP activity and specificity of the C9orf72 complex
title_fullStr	Structural basis for the ARF GAP activity and specificity of the C9orf72 complex
title_full_unstemmed	Structural basis for the ARF GAP activity and specificity of the C9orf72 complex
title_sort	structural basis for the arf gap activity and specificity of the c9orf72 complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/68ecccfd058a41458fb45ddd911e60ed
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Structural basis for the ARF GAP activity and specificity of the C9orf72 complex

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