The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus...

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Autores principales:	Runqiu Jiang, Junwei Tang, Yun Chen, Lei Deng, Jie Ji, Yu Xie, Ke Wang, Wei Jia, Wen-Ming Chu, Beicheng Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68f1a8b6ea584d59a60191c25afd516c
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spelling	oai:doaj.org-article:68f1a8b6ea584d59a60191c25afd516c2021-12-02T14:40:56ZThe long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion10.1038/ncomms151292041-1723https://doaj.org/article/68f1a8b6ea584d59a60191c25afd516c2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15129https://doaj.org/toc/2041-1723The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression.Runqiu JiangJunwei TangYun ChenLei DengJie JiYu XieKe WangWei JiaWen-Ming ChuBeicheng SunNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Runqiu Jiang Junwei Tang Yun Chen Lei Deng Jie Ji Yu Xie Ke Wang Wei Jia Wen-Ming Chu Beicheng Sun The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
description	The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression.
format	article
author	Runqiu Jiang Junwei Tang Yun Chen Lei Deng Jie Ji Yu Xie Ke Wang Wei Jia Wen-Ming Chu Beicheng Sun
author_facet	Runqiu Jiang Junwei Tang Yun Chen Lei Deng Jie Ji Yu Xie Ke Wang Wei Jia Wen-Ming Chu Beicheng Sun
author_sort	Runqiu Jiang
title	The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_short	The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_full	The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_fullStr	The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_full_unstemmed	The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_sort	long noncoding rna lnc-egfr stimulates t-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68f1a8b6ea584d59a60191c25afd516c
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The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

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