Effect of estrogens on skin aging and the potential role of SERMs

Susan Stevenson1, Julie Thornton21Burns & Plastic Surgery Research Unit, 2Cutaneous Research, Medical Biosciences, School of Life Sciences, University of Bradford, Bradford, UKAbstract: In humans, structural and functional changes attributable to aging are more visibly evident in the skin th...

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Autores principales:	Susan Stevenson, Julie Thornton
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/68f3dafd75e74b3f96d49696f94f9e81
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id	oai:doaj.org-article:68f3dafd75e74b3f96d49696f94f9e81
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spelling	oai:doaj.org-article:68f3dafd75e74b3f96d49696f94f9e812021-12-02T03:57:32ZEffect of estrogens on skin aging and the potential role of SERMs1178-1998https://doaj.org/article/68f3dafd75e74b3f96d49696f94f9e812007-10-01T00:00:00Zhttps://www.dovepress.com/effect-of-estrogens-on-skin-aging-and-the-potential-role-of-serms-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Susan Stevenson1, Julie Thornton21Burns & Plastic Surgery Research Unit, 2Cutaneous Research, Medical Biosciences, School of Life Sciences, University of Bradford, Bradford, UKAbstract: In humans, structural and functional changes attributable to aging are more visibly evident in the skin than in any other organ. Estrogens have significant effects on skin physiology and modulate epidermal keratinocytes, dermal fibroblasts and melanocytes, in addition to skin appendages including the hair follicle and the sebaceous gland. Importantly, skin aging can be significantly delayed by the administration of estrogen. This paper reviews the effects of estrogens on skin and the mechanisms by which estrogens can alleviate the changes due to aging that occur in human skin. The relevance of estrogen replacement therapy (HRT) in postmenopausal women and the potential value of selective estrogen receptor modulators (SERMs) as a therapy for diminishing skin aging are also highlighted.Keywords: estrogen receptors, skin, menopause, SERMs, HRTSusan StevensonJulie ThorntonDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 283-297 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Susan Stevenson Julie Thornton Effect of estrogens on skin aging and the potential role of SERMs
description	Susan Stevenson1, Julie Thornton21Burns & Plastic Surgery Research Unit, 2Cutaneous Research, Medical Biosciences, School of Life Sciences, University of Bradford, Bradford, UKAbstract: In humans, structural and functional changes attributable to aging are more visibly evident in the skin than in any other organ. Estrogens have significant effects on skin physiology and modulate epidermal keratinocytes, dermal fibroblasts and melanocytes, in addition to skin appendages including the hair follicle and the sebaceous gland. Importantly, skin aging can be significantly delayed by the administration of estrogen. This paper reviews the effects of estrogens on skin and the mechanisms by which estrogens can alleviate the changes due to aging that occur in human skin. The relevance of estrogen replacement therapy (HRT) in postmenopausal women and the potential value of selective estrogen receptor modulators (SERMs) as a therapy for diminishing skin aging are also highlighted.Keywords: estrogen receptors, skin, menopause, SERMs, HRT
format	article
author	Susan Stevenson Julie Thornton
author_facet	Susan Stevenson Julie Thornton
author_sort	Susan Stevenson
title	Effect of estrogens on skin aging and the potential role of SERMs
title_short	Effect of estrogens on skin aging and the potential role of SERMs
title_full	Effect of estrogens on skin aging and the potential role of SERMs
title_fullStr	Effect of estrogens on skin aging and the potential role of SERMs
title_full_unstemmed	Effect of estrogens on skin aging and the potential role of SERMs
title_sort	effect of estrogens on skin aging and the potential role of serms
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/68f3dafd75e74b3f96d49696f94f9e81
work_keys_str_mv	AT susanstevenson effectofestrogensonskinagingandthepotentialroleofserms AT juliethornton effectofestrogensonskinagingandthepotentialroleofserms
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Effect of estrogens on skin aging and the potential role of SERMs

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