Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions

Abstract During development, cell division often generates two daughters with different developmental fates. Distinct daughter identities can result from the physical polarity and size asymmetry itself, as well as the subsequent activation of distinct fate programmes in each daughter. Asymmetric div...

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Autores principales:	Siyu Serena Ding, Alison Woollard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68f41940da504c10bb9ca3f0ac8a4d02
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spelling	oai:doaj.org-article:68f41940da504c10bb9ca3f0ac8a4d022021-12-02T11:52:59ZNon-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions10.1038/s41598-017-01675-72045-2322https://doaj.org/article/68f41940da504c10bb9ca3f0ac8a4d022017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01675-7https://doaj.org/toc/2045-2322Abstract During development, cell division often generates two daughters with different developmental fates. Distinct daughter identities can result from the physical polarity and size asymmetry itself, as well as the subsequent activation of distinct fate programmes in each daughter. Asymmetric divisions are a feature of the C. elegans seam lineage, in which a series of post-embryonic, stem-like asymmetric divisions give rise to an anterior daughter that differentiates and a posterior daughter that continues to divide. Here we have investigated the role of non-muscle myosin II (nmy-2) in these asymmetric divisions. We show that nmy-2 does not appear to be involved in generating physical division asymmetry, but nonetheless is important for specifying differential cell fate. While cell polarity appears normal, and chromosome and furrow positioning remains unchanged when nmy-2 is inactivated, seam cell loss occurs through inappropriate terminal differentiation of posterior daughters. This reveals a role for nmy-2 in cell fate determination not obviously linked to the primary polarity determination mechanisms it has been previously associated with.Siyu Serena DingAlison WoollardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Siyu Serena Ding Alison Woollard Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions
description	Abstract During development, cell division often generates two daughters with different developmental fates. Distinct daughter identities can result from the physical polarity and size asymmetry itself, as well as the subsequent activation of distinct fate programmes in each daughter. Asymmetric divisions are a feature of the C. elegans seam lineage, in which a series of post-embryonic, stem-like asymmetric divisions give rise to an anterior daughter that differentiates and a posterior daughter that continues to divide. Here we have investigated the role of non-muscle myosin II (nmy-2) in these asymmetric divisions. We show that nmy-2 does not appear to be involved in generating physical division asymmetry, but nonetheless is important for specifying differential cell fate. While cell polarity appears normal, and chromosome and furrow positioning remains unchanged when nmy-2 is inactivated, seam cell loss occurs through inappropriate terminal differentiation of posterior daughters. This reveals a role for nmy-2 in cell fate determination not obviously linked to the primary polarity determination mechanisms it has been previously associated with.
format	article
author	Siyu Serena Ding Alison Woollard
author_facet	Siyu Serena Ding Alison Woollard
author_sort	Siyu Serena Ding
title	Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions
title_short	Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions
title_full	Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions
title_fullStr	Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions
title_full_unstemmed	Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions
title_sort	non-muscle myosin ii is required for correct fate specification in the caenorhabditis elegans seam cell divisions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68f41940da504c10bb9ca3f0ac8a4d02
work_keys_str_mv	AT siyuserenading nonmusclemyosiniiisrequiredforcorrectfatespecificationinthecaenorhabditiselegansseamcelldivisions AT alisonwoollard nonmusclemyosiniiisrequiredforcorrectfatespecificationinthecaenorhabditiselegansseamcelldivisions
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Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions

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