Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal

Abstract The orexinergic system of the lateral hypothalamus plays a crucial role in maintaining wakefulness and mediating arousal in a circadian time-dependent manner. Due to the extensive connections of orexinergic neurons, both orexins (OXA and OXB) exert mainly excitatory effects upon remote brai...

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Autores principales:	Lukasz Chrobok, Katarzyna Palus-Chramiec, Anna Chrzanowska, Mariusz Kepczynski, Marian Henryk Lewandowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68f4568cea5f49b7a0f079cff6a5e51d
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spelling	oai:doaj.org-article:68f4568cea5f49b7a0f079cff6a5e51d2021-12-02T16:06:30ZMultiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal10.1038/s41598-017-08202-82045-2322https://doaj.org/article/68f4568cea5f49b7a0f079cff6a5e51d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08202-8https://doaj.org/toc/2045-2322Abstract The orexinergic system of the lateral hypothalamus plays a crucial role in maintaining wakefulness and mediating arousal in a circadian time-dependent manner. Due to the extensive connections of orexinergic neurons, both orexins (OXA and OXB) exert mainly excitatory effects upon remote brain areas, including the thalamus. The dorsal lateral geniculate nucleus (DLG) is a relay thalamic centre for the visual system. Its thalamo-cortical (TC) neurons convey photic information from the retina to the primary visual cortex. The present study shows that orexins are powerful modulators of neuronal activity in the DLG. OXA directly depolarised the majority of neurons tested, acting predominately on postsynaptic OX2 receptors. Moreover, OXA was found to increase excitability and enhance neuronal responses to both glutamate and γ-aminobutyric acid (GABA). Mechanistic studies showed the involvement of voltage-gated calcium currents and GIRK channels in the observed depolarisations. Immunohistochemical staining showed sparse orexinergic innervation of the DLG during the light phase, with increased density at night. We hypothesise that the depolarising effects of orexins upon DLG neurons may facilitate signal transmission through the visual thalamo-cortical pathway during behavioural arousal. Thus, the action of orexin on DLG TC neurons may underlie the circadian/behavioural modulation of vision.Lukasz ChrobokKatarzyna Palus-ChramiecAnna ChrzanowskaMariusz KepczynskiMarian Henryk LewandowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lukasz Chrobok Katarzyna Palus-Chramiec Anna Chrzanowska Mariusz Kepczynski Marian Henryk Lewandowski Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal
description	Abstract The orexinergic system of the lateral hypothalamus plays a crucial role in maintaining wakefulness and mediating arousal in a circadian time-dependent manner. Due to the extensive connections of orexinergic neurons, both orexins (OXA and OXB) exert mainly excitatory effects upon remote brain areas, including the thalamus. The dorsal lateral geniculate nucleus (DLG) is a relay thalamic centre for the visual system. Its thalamo-cortical (TC) neurons convey photic information from the retina to the primary visual cortex. The present study shows that orexins are powerful modulators of neuronal activity in the DLG. OXA directly depolarised the majority of neurons tested, acting predominately on postsynaptic OX2 receptors. Moreover, OXA was found to increase excitability and enhance neuronal responses to both glutamate and γ-aminobutyric acid (GABA). Mechanistic studies showed the involvement of voltage-gated calcium currents and GIRK channels in the observed depolarisations. Immunohistochemical staining showed sparse orexinergic innervation of the DLG during the light phase, with increased density at night. We hypothesise that the depolarising effects of orexins upon DLG neurons may facilitate signal transmission through the visual thalamo-cortical pathway during behavioural arousal. Thus, the action of orexin on DLG TC neurons may underlie the circadian/behavioural modulation of vision.
format	article
author	Lukasz Chrobok Katarzyna Palus-Chramiec Anna Chrzanowska Mariusz Kepczynski Marian Henryk Lewandowski
author_facet	Lukasz Chrobok Katarzyna Palus-Chramiec Anna Chrzanowska Mariusz Kepczynski Marian Henryk Lewandowski
author_sort	Lukasz Chrobok
title	Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal
title_short	Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal
title_full	Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal
title_fullStr	Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal
title_full_unstemmed	Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal
title_sort	multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68f4568cea5f49b7a0f079cff6a5e51d
work_keys_str_mv	AT lukaszchrobok multipleexcitatoryactionsoforexinsuponthalamocorticalneuronsindorsallateralgeniculatenucleusimplicationsforvisionmodulationbyarousal AT katarzynapaluschramiec multipleexcitatoryactionsoforexinsuponthalamocorticalneuronsindorsallateralgeniculatenucleusimplicationsforvisionmodulationbyarousal AT annachrzanowska multipleexcitatoryactionsoforexinsuponthalamocorticalneuronsindorsallateralgeniculatenucleusimplicationsforvisionmodulationbyarousal AT mariuszkepczynski multipleexcitatoryactionsoforexinsuponthalamocorticalneuronsindorsallateralgeniculatenucleusimplicationsforvisionmodulationbyarousal AT marianhenryklewandowski multipleexcitatoryactionsoforexinsuponthalamocorticalneuronsindorsallateralgeniculatenucleusimplicationsforvisionmodulationbyarousal
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Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal

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