Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma

Marcelo Ayala,1–3 Filip Cuklev41Eye Department, Skaraborg Hospital, Skövde, Sweden; 2Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; 3Karolinska Institute, Solna, Sweden; 4TATAA Biocenter, Gothenburg, SwedenBackground: Glaucoma is an optic neuropathy associated wit...

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Autores principales:	Ayala M, Cuklev F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	exfoliation glaucoma gene expression unilateral. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/68f851524a7443ecbe62ef463f865b84
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spelling	oai:doaj.org-article:68f851524a7443ecbe62ef463f865b842021-12-02T00:08:54ZIndistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma1177-5483https://doaj.org/article/68f851524a7443ecbe62ef463f865b842018-07-01T00:00:00Zhttps://www.dovepress.com/indistinguishable-gene-expression-between-healthy-eyes-and-eyes-with-u-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Marcelo Ayala,1–3 Filip Cuklev41Eye Department, Skaraborg Hospital, Skövde, Sweden; 2Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; 3Karolinska Institute, Solna, Sweden; 4TATAA Biocenter, Gothenburg, SwedenBackground: Glaucoma is an optic neuropathy associated with visual field loss. There are different types of glaucoma, among them exfoliative glaucoma. Glaucoma can present as unilateral or bilateral. The present study aimed to show the association between gene expression and exfoliation in unilateral glaucoma cases.Methods: Included patients were suffering from exfoliative glaucoma in one eye, meanwhile the other eye was healthy and used as a control. Lens capsule and conjunctival biopsies were taken from both eyes. Gene expression was analyzed.Results: Both groups were completely different at baseline regarding intraocular pressure, visual acuity before the operation, visual field damage, optic nerve damage, etc. As for gene expression, the only significant difference was found in CYP1B1 from lens capsules. None of the other genes studied showed differential expression in either lens capsules or conjunctival biopsies.Conclusion: No difference in gene expression was found between eyes with and without exfoliative glaucoma. Exfoliative glaucoma seems to be a bilateral disease, though the phenotype is not always clinically present.Keywords: exfoliation, glaucoma, gene expression, unilateralAyala MCuklev FDove Medical Pressarticleexfoliationglaucomagene expressionunilateral.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1155-1162 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	exfoliation glaucoma gene expression unilateral. Ophthalmology RE1-994
spellingShingle	exfoliation glaucoma gene expression unilateral. Ophthalmology RE1-994 Ayala M Cuklev F Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma
description	Marcelo Ayala,1–3 Filip Cuklev41Eye Department, Skaraborg Hospital, Skövde, Sweden; 2Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; 3Karolinska Institute, Solna, Sweden; 4TATAA Biocenter, Gothenburg, SwedenBackground: Glaucoma is an optic neuropathy associated with visual field loss. There are different types of glaucoma, among them exfoliative glaucoma. Glaucoma can present as unilateral or bilateral. The present study aimed to show the association between gene expression and exfoliation in unilateral glaucoma cases.Methods: Included patients were suffering from exfoliative glaucoma in one eye, meanwhile the other eye was healthy and used as a control. Lens capsule and conjunctival biopsies were taken from both eyes. Gene expression was analyzed.Results: Both groups were completely different at baseline regarding intraocular pressure, visual acuity before the operation, visual field damage, optic nerve damage, etc. As for gene expression, the only significant difference was found in CYP1B1 from lens capsules. None of the other genes studied showed differential expression in either lens capsules or conjunctival biopsies.Conclusion: No difference in gene expression was found between eyes with and without exfoliative glaucoma. Exfoliative glaucoma seems to be a bilateral disease, though the phenotype is not always clinically present.Keywords: exfoliation, glaucoma, gene expression, unilateral
format	article
author	Ayala M Cuklev F
author_facet	Ayala M Cuklev F
author_sort	Ayala M
title	Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma
title_short	Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma
title_full	Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma
title_fullStr	Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma
title_full_unstemmed	Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma
title_sort	indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/68f851524a7443ecbe62ef463f865b84
work_keys_str_mv	AT ayalam indistinguishablegeneexpressionbetweenhealthyeyesandeyeswithunilateralexfoliativeglaucoma AT cuklevf indistinguishablegeneexpressionbetweenhealthyeyesandeyeswithunilateralexfoliativeglaucoma
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Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma

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