Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.

Toll-like receptors (TLRs) participate in the defence against bacterial infections that are common in patients with Chronic Obstructive Pulmonary Disease (COPD). We studied all tagging SNPs in TLR2 and TLR4 and their associations with the level and change over time of both FEV(1) and sputum inflamma...

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Autores principales:	Simona E Budulac, H Marike Boezen, Pieter S Hiemstra, Therese S Lapperre, Judith M Vonk, Wim Timens, Dirkje S Postma, GLUCOLD study group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68f893757b8d48599b02d4cca28da0af
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spelling	oai:doaj.org-article:68f893757b8d48599b02d4cca28da0af2021-11-18T07:07:17ZToll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.1932-620310.1371/journal.pone.0043124https://doaj.org/article/68f893757b8d48599b02d4cca28da0af2012-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0043124https://doaj.org/toc/1932-6203Toll-like receptors (TLRs) participate in the defence against bacterial infections that are common in patients with Chronic Obstructive Pulmonary Disease (COPD). We studied all tagging SNPs in TLR2 and TLR4 and their associations with the level and change over time of both FEV(1) and sputum inflammatory cells in moderate-to-severe COPD. Nine TLR2 SNPs and 17 TLR4 SNPs were genotyped in 110 COPD patients. Associations of SNPs with lung function and inflammatory cells in induced sputum were analyzed cross-sectionally with linear regression and longitudinally with linear mixed-effect models. Two SNPs in TLR2 (rs1898830 and rs11938228) were associated with a lower level of FEV(1) and accelerated decline of FEV(1) and higher numbers of sputum inflammatory cells. None of the TLR4 SNPs was associated with FEV(1) level. Eleven out of 17 SNPs were associated with FEV(1) decline, including rs12377632 and rs10759931, which were additionally associated with higher numbers of sputum inflammatory cells at baseline and with increase over time. This is the first longitudinal study showing that tagging SNPs in TLR2 and TLR4 are associated with the level and decline of lung function as well as with inflammatory cell numbers in induced sputum in COPD patients, suggesting a role in the severity and progression of COPD.Simona E BudulacH Marike BoezenPieter S HiemstraTherese S LapperreJudith M VonkWim TimensDirkje S PostmaGLUCOLD study groupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43124 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simona E Budulac H Marike Boezen Pieter S Hiemstra Therese S Lapperre Judith M Vonk Wim Timens Dirkje S Postma GLUCOLD study group Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.
description	Toll-like receptors (TLRs) participate in the defence against bacterial infections that are common in patients with Chronic Obstructive Pulmonary Disease (COPD). We studied all tagging SNPs in TLR2 and TLR4 and their associations with the level and change over time of both FEV(1) and sputum inflammatory cells in moderate-to-severe COPD. Nine TLR2 SNPs and 17 TLR4 SNPs were genotyped in 110 COPD patients. Associations of SNPs with lung function and inflammatory cells in induced sputum were analyzed cross-sectionally with linear regression and longitudinally with linear mixed-effect models. Two SNPs in TLR2 (rs1898830 and rs11938228) were associated with a lower level of FEV(1) and accelerated decline of FEV(1) and higher numbers of sputum inflammatory cells. None of the TLR4 SNPs was associated with FEV(1) level. Eleven out of 17 SNPs were associated with FEV(1) decline, including rs12377632 and rs10759931, which were additionally associated with higher numbers of sputum inflammatory cells at baseline and with increase over time. This is the first longitudinal study showing that tagging SNPs in TLR2 and TLR4 are associated with the level and decline of lung function as well as with inflammatory cell numbers in induced sputum in COPD patients, suggesting a role in the severity and progression of COPD.
format	article
author	Simona E Budulac H Marike Boezen Pieter S Hiemstra Therese S Lapperre Judith M Vonk Wim Timens Dirkje S Postma GLUCOLD study group
author_facet	Simona E Budulac H Marike Boezen Pieter S Hiemstra Therese S Lapperre Judith M Vonk Wim Timens Dirkje S Postma GLUCOLD study group
author_sort	Simona E Budulac
title	Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.
title_short	Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.
title_full	Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.
title_fullStr	Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.
title_full_unstemmed	Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.
title_sort	toll-like receptor (tlr2 and tlr4) polymorphisms and chronic obstructive pulmonary disease.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/68f893757b8d48599b02d4cca28da0af
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Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.

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