A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)

Background: The aim of the present study was to fabricate double layered scaffolds of electrospun polycaprolactone (PCL) and poly(ethylene oxide) (PEO). The electrospun PCL fibers were functionalized with wintergreen oil (WO) as a novel approach to prevent vascular grafts failure due to thrombosis b...

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Autores principales:	Shima Eldurini, Bothaina M. Abd El-Hady, Medhat W. Shafaa, Abdul Aziz M. Gad, Emad Tolba
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Polycaprolactone (PCL) Poly(ethylene oxide) (PEO) Wintergreen oil (WO) Electrospun vascular grafts Blood compatibility Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/68fd2ee7a27a41d99a0e1389c6c3fc38
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spelling	oai:doaj.org-article:68fd2ee7a27a41d99a0e1389c6c3fc382021-11-28T04:33:00ZA multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)2319-417010.1016/j.bj.2020.04.008https://doaj.org/article/68fd2ee7a27a41d99a0e1389c6c3fc382021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2319417020300457https://doaj.org/toc/2319-4170Background: The aim of the present study was to fabricate double layered scaffolds of electrospun polycaprolactone (PCL) and poly(ethylene oxide) (PEO). The electrospun PCL fibers were functionalized with wintergreen oil (WO) as a novel approach to prevent vascular grafts failure due to thrombosis by adjusting biomaterial–blood interactions. Methods: PCL tubular scaffolds were prepared by electrospinning approach and coated with PEO as a hydrophilic polymer. The single and double layered scaffolds were characterized in terms of their morphological, chemical properties -as well as-hemocompatibility assays (i.e. prothrombin time, hemolysis percentage and platelets adhesion). Moreover, the antioxidant potential of WO-PCL samples were measured by 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radical assay. Results: The results demonstrated that incorporation of WO during the electrospinning process decreased the PCL fiber diameter. In addition, the prothrombine time assay shows that WO could be used to lower the electrospun PCL fiber tendency to induce blood clotting. Moreover, SEM observations of platelets adhesion of both single and double layered PCL/PEO scaffolds fiber shows an increase of platelets number, compared with the scaffolds containing WO. Conclusions: The antioxidant potential and blood compatibility measurements of WO-PCL/PEO samples highlight the approach made so far as an ideal synthetic small size vascular grafts to overcome autogenous grafts shortages and drawbacks.Shima ElduriniBothaina M. Abd El-HadyMedhat W. ShafaaAbdul Aziz M. GadEmad TolbaElsevierarticlePolycaprolactone (PCL)Poly(ethylene oxide) (PEO)Wintergreen oil (WO)Electrospun vascular graftsBlood compatibilityMedicine (General)R5-920Biology (General)QH301-705.5ENBiomedical Journal, Vol 44, Iss 5, Pp 589-597 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polycaprolactone (PCL) Poly(ethylene oxide) (PEO) Wintergreen oil (WO) Electrospun vascular grafts Blood compatibility Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	Polycaprolactone (PCL) Poly(ethylene oxide) (PEO) Wintergreen oil (WO) Electrospun vascular grafts Blood compatibility Medicine (General) R5-920 Biology (General) QH301-705.5 Shima Eldurini Bothaina M. Abd El-Hady Medhat W. Shafaa Abdul Aziz M. Gad Emad Tolba A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)
description	Background: The aim of the present study was to fabricate double layered scaffolds of electrospun polycaprolactone (PCL) and poly(ethylene oxide) (PEO). The electrospun PCL fibers were functionalized with wintergreen oil (WO) as a novel approach to prevent vascular grafts failure due to thrombosis by adjusting biomaterial–blood interactions. Methods: PCL tubular scaffolds were prepared by electrospinning approach and coated with PEO as a hydrophilic polymer. The single and double layered scaffolds were characterized in terms of their morphological, chemical properties -as well as-hemocompatibility assays (i.e. prothrombin time, hemolysis percentage and platelets adhesion). Moreover, the antioxidant potential of WO-PCL samples were measured by 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radical assay. Results: The results demonstrated that incorporation of WO during the electrospinning process decreased the PCL fiber diameter. In addition, the prothrombine time assay shows that WO could be used to lower the electrospun PCL fiber tendency to induce blood clotting. Moreover, SEM observations of platelets adhesion of both single and double layered PCL/PEO scaffolds fiber shows an increase of platelets number, compared with the scaffolds containing WO. Conclusions: The antioxidant potential and blood compatibility measurements of WO-PCL/PEO samples highlight the approach made so far as an ideal synthetic small size vascular grafts to overcome autogenous grafts shortages and drawbacks.
format	article
author	Shima Eldurini Bothaina M. Abd El-Hady Medhat W. Shafaa Abdul Aziz M. Gad Emad Tolba
author_facet	Shima Eldurini Bothaina M. Abd El-Hady Medhat W. Shafaa Abdul Aziz M. Gad Emad Tolba
author_sort	Shima Eldurini
title	A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)
title_short	A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)
title_full	A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)
title_fullStr	A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)
title_full_unstemmed	A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)
title_sort	multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/68fd2ee7a27a41d99a0e1389c6c3fc38
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A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide)

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