Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.

Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may inf...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nik-Madihah Nik-Azis, Nurulhuda Mohd, Fazalina Mohd Fadzilah, Nor Hazla Mohamed Haflah, Mohd Shahrir Mohamed Said, Badiah Baharin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68fde5ed324649038e0a96221ab9c8fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:68fde5ed324649038e0a96221ab9c8fe
record_format	dspace
spelling	oai:doaj.org-article:68fde5ed324649038e0a96221ab9c8fe2021-12-02T20:10:20ZRheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.1932-620310.1371/journal.pone.0252859https://doaj.org/article/68fde5ed324649038e0a96221ab9c8fe2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252859https://doaj.org/toc/1932-6203Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Medical, serological and radiological (Sharp/van der Heijde) records were assessed. Functional status was assessed using the administered Health Assessment Questionnaire. Moreover, disease parameters, including disease activity (DAS28-ESR) and anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) seropositivity were evaluated. Periodontitis was higher in RA (71.54%) compared with controls (54.62%). The stage of periodontitis experienced by ACPA-positive participants were higher than APCA-negative participants. The probing pocket depth and recession experienced by RF-positive participants were higher than those who were RF-negative. RA participants on methotrexate had lower clinical attachment loss and lower periodontal probing depth compared with participants on a combination methotrexate and other disease-modifying antirheumatic drugs. Participants taking corticosteroids had lower gingival index scores. The association between seropositivity and the type of medications taken with periodontal health parameters in this group of patients suggests that both seropositivity and medications taken are important modifiers in the relationship between periodontitis and RA.Nik-Madihah Nik-AzisNurulhuda MohdFazalina Mohd FadzilahNor Hazla Mohamed HaflahMohd Shahrir Mohamed SaidBadiah BaharinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252859 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nik-Madihah Nik-Azis Nurulhuda Mohd Fazalina Mohd Fadzilah Nor Hazla Mohamed Haflah Mohd Shahrir Mohamed Said Badiah Baharin Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.
description	Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Medical, serological and radiological (Sharp/van der Heijde) records were assessed. Functional status was assessed using the administered Health Assessment Questionnaire. Moreover, disease parameters, including disease activity (DAS28-ESR) and anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) seropositivity were evaluated. Periodontitis was higher in RA (71.54%) compared with controls (54.62%). The stage of periodontitis experienced by ACPA-positive participants were higher than APCA-negative participants. The probing pocket depth and recession experienced by RF-positive participants were higher than those who were RF-negative. RA participants on methotrexate had lower clinical attachment loss and lower periodontal probing depth compared with participants on a combination methotrexate and other disease-modifying antirheumatic drugs. Participants taking corticosteroids had lower gingival index scores. The association between seropositivity and the type of medications taken with periodontal health parameters in this group of patients suggests that both seropositivity and medications taken are important modifiers in the relationship between periodontitis and RA.
format	article
author	Nik-Madihah Nik-Azis Nurulhuda Mohd Fazalina Mohd Fadzilah Nor Hazla Mohamed Haflah Mohd Shahrir Mohamed Said Badiah Baharin
author_facet	Nik-Madihah Nik-Azis Nurulhuda Mohd Fazalina Mohd Fadzilah Nor Hazla Mohamed Haflah Mohd Shahrir Mohamed Said Badiah Baharin
author_sort	Nik-Madihah Nik-Azis
title	Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.
title_short	Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.
title_full	Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.
title_fullStr	Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.
title_full_unstemmed	Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.
title_sort	rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: a case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/68fde5ed324649038e0a96221ab9c8fe
work_keys_str_mv	AT nikmadihahnikazis rheumatoidarthritisserotypeandsyntheticdiseasemodifyingantirheumaticdrugsinpatientswithperiodontitisacasecontrolstudy AT nurulhudamohd rheumatoidarthritisserotypeandsyntheticdiseasemodifyingantirheumaticdrugsinpatientswithperiodontitisacasecontrolstudy AT fazalinamohdfadzilah rheumatoidarthritisserotypeandsyntheticdiseasemodifyingantirheumaticdrugsinpatientswithperiodontitisacasecontrolstudy AT norhazlamohamedhaflah rheumatoidarthritisserotypeandsyntheticdiseasemodifyingantirheumaticdrugsinpatientswithperiodontitisacasecontrolstudy AT mohdshahrirmohamedsaid rheumatoidarthritisserotypeandsyntheticdiseasemodifyingantirheumaticdrugsinpatientswithperiodontitisacasecontrolstudy AT badiahbaharin rheumatoidarthritisserotypeandsyntheticdiseasemodifyingantirheumaticdrugsinpatientswithperiodontitisacasecontrolstudy
_version_	1718375004244017152

Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.

Ejemplares similares