Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis

Abstract Background In post-menopausal women, estrogen deficiency leads to instability between bone formation and resorption which is regulated by osteoclastogenic cytokines leading to resorption. Interleukin-17 (IL-17) a proinflammatory cytokine has been found as an important regulator of osteoclas...

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Autores principales:	Reem El-Mallah, Azza A. Saab, Nagwa Nassar
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Interleukin-17 Osteoporosis Serum estradiol DEXA Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/69061e4f53cc4b838d7cff4444cb3579
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spelling	oai:doaj.org-article:69061e4f53cc4b838d7cff4444cb35792021-11-28T12:09:35ZSerum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis10.1186/s43166-021-00083-01110-161X2090-3235https://doaj.org/article/69061e4f53cc4b838d7cff4444cb35792021-11-01T00:00:00Zhttps://doi.org/10.1186/s43166-021-00083-0https://doaj.org/toc/1110-161Xhttps://doaj.org/toc/2090-3235Abstract Background In post-menopausal women, estrogen deficiency leads to instability between bone formation and resorption which is regulated by osteoclastogenic cytokines leading to resorption. Interleukin-17 (IL-17) a proinflammatory cytokine has been found as an important regulator of osteoclast-genesis induced by estrogen deficiency in favor of bone loss in animal studies. The study aimed to evaluate levels of IL-17 and estrogen (E2) in relation to bone mineral density (BMD) and risk of fracture in postmenopausal women with and without osteoporosis. Results IL-17 levels were significantly higher and E2 levels were significantly lower in the osteoporotic group compared to the non-osteoporotic group (P value ≤ 0.01). There was a highly significant difference in DEXA score and FRAX index between two groups: with higher values of FRAX and lower values of DEXA score among osteoporotic group (P value ≤ 0.01). IL-17 was inversely correlated to estrogen level and highly significant negative correlation with DEXA as well as a highly significant positive one with FRAX index. IL-17 serum level was able to diagnose osteoporosis at a cutoff level of > 80 pg/mL with 100% sensitivity, 100% specificity, 100% positive predictive value (PPV), and 100% negative predictive value (NPV). Conclusions Serum IL-17 was significantly elevated in osteoporotic postmenopausal women when compared to healthy postmenopausal ones and was inversely correlated with estrogen level and DEXA.Reem El-MallahAzza A. SaabNagwa NassarSpringerOpenarticleInterleukin-17OsteoporosisSerum estradiolDEXADiseases of the musculoskeletal systemRC925-935ENEgyptian Rheumatology and Rehabilitation, Vol 48, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Interleukin-17 Osteoporosis Serum estradiol DEXA Diseases of the musculoskeletal system RC925-935
spellingShingle	Interleukin-17 Osteoporosis Serum estradiol DEXA Diseases of the musculoskeletal system RC925-935 Reem El-Mallah Azza A. Saab Nagwa Nassar Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis
description	Abstract Background In post-menopausal women, estrogen deficiency leads to instability between bone formation and resorption which is regulated by osteoclastogenic cytokines leading to resorption. Interleukin-17 (IL-17) a proinflammatory cytokine has been found as an important regulator of osteoclast-genesis induced by estrogen deficiency in favor of bone loss in animal studies. The study aimed to evaluate levels of IL-17 and estrogen (E2) in relation to bone mineral density (BMD) and risk of fracture in postmenopausal women with and without osteoporosis. Results IL-17 levels were significantly higher and E2 levels were significantly lower in the osteoporotic group compared to the non-osteoporotic group (P value ≤ 0.01). There was a highly significant difference in DEXA score and FRAX index between two groups: with higher values of FRAX and lower values of DEXA score among osteoporotic group (P value ≤ 0.01). IL-17 was inversely correlated to estrogen level and highly significant negative correlation with DEXA as well as a highly significant positive one with FRAX index. IL-17 serum level was able to diagnose osteoporosis at a cutoff level of > 80 pg/mL with 100% sensitivity, 100% specificity, 100% positive predictive value (PPV), and 100% negative predictive value (NPV). Conclusions Serum IL-17 was significantly elevated in osteoporotic postmenopausal women when compared to healthy postmenopausal ones and was inversely correlated with estrogen level and DEXA.
format	article
author	Reem El-Mallah Azza A. Saab Nagwa Nassar
author_facet	Reem El-Mallah Azza A. Saab Nagwa Nassar
author_sort	Reem El-Mallah
title	Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis
title_short	Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis
title_full	Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis
title_fullStr	Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis
title_full_unstemmed	Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis
title_sort	serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/69061e4f53cc4b838d7cff4444cb3579
work_keys_str_mv	AT reemelmallah seruminterleukin17andestradiollevelsinpostmenopausalwomeninrelationtoosteoporosis AT azzaasaab seruminterleukin17andestradiollevelsinpostmenopausalwomeninrelationtoosteoporosis AT nagwanassar seruminterleukin17andestradiollevelsinpostmenopausalwomeninrelationtoosteoporosis
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Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis

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