Molecular signaling in temporomandibular joint osteoarthritis

Objective: Temporomandibular joint (TMJ) osteoarthritis (OA) is a type of TMJ disorders with clinical symptoms of pain, movement limitation, cartilage degeneration and joint dysfunction. This review article is aiming to summarize recent findings on signaling pathways involved in TMJ OA development a...

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Autores principales:	Ke Lu, Feng Ma, Dan Yi, Huan Yu, Liping Tong, Di Chen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Temporomandibular joint Osteoarthritis Cartilage degradation Mechanical loading Molecular signaling Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/690717c417d04361afad61094381cf5c
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spelling	oai:doaj.org-article:690717c417d04361afad61094381cf5c2021-11-28T04:32:21ZMolecular signaling in temporomandibular joint osteoarthritis2214-031X10.1016/j.jot.2021.07.001https://doaj.org/article/690717c417d04361afad61094381cf5c2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214031X21000504https://doaj.org/toc/2214-031XObjective: Temporomandibular joint (TMJ) osteoarthritis (OA) is a type of TMJ disorders with clinical symptoms of pain, movement limitation, cartilage degeneration and joint dysfunction. This review article is aiming to summarize recent findings on signaling pathways involved in TMJ OA development and progression. Methods: Most recent findings in TMJ OA studies have been reviewed and cited. Results: TMJ OA is caused by inflammation, abnormal mechanical loading and genetic abnormalities. The molecular mechanisms related to TMJ OA have been determined using different genetic mouse models. Recent studies demonstrated that several signaling pathways are involved in TMJ OA pathology, including Wnt/β-catenin, TGF-β and BMP, Indian Hedgehog, FGF, NF-κB, and Notch pathways, which are summarized in this review article. Alterations of these signaling pathways lead to the pathological changes in TMJ tissues, affecting cartilage matrix degradation, catabolic metabolism and chondrocyte apoptosis. Conclusion: Multiple signaling pathways were involved in the pathological process of TMJ OA. New therapeutic strategies, such as stem cell application, gene editing and other techniques may be utilized for TMJ OA treatment. The translational potential of this article: TMJ OA is a most important subtype of TMJ disorders and may lead to substantial joint pain, dysfunction, dental malocclusion, and reduced health-related quality of life. This review article summarized current findings of signaling pathways involved in TMJ OA, including Wnt/β-catenin, TGF-β and BMP, Indian Hedgehog, FGF, NF-κB, and Notch pathways, to better understand the pathological mechanisms of TMJ OA and define the molecular targets for TMJ OA treatment.Ke LuFeng MaDan YiHuan YuLiping TongDi ChenElsevierarticleTemporomandibular jointOsteoarthritisCartilage degradationMechanical loadingMolecular signalingDiseases of the musculoskeletal systemRC925-935ENJournal of Orthopaedic Translation, Vol 32, Iss , Pp 21-27 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Temporomandibular joint Osteoarthritis Cartilage degradation Mechanical loading Molecular signaling Diseases of the musculoskeletal system RC925-935
spellingShingle	Temporomandibular joint Osteoarthritis Cartilage degradation Mechanical loading Molecular signaling Diseases of the musculoskeletal system RC925-935 Ke Lu Feng Ma Dan Yi Huan Yu Liping Tong Di Chen Molecular signaling in temporomandibular joint osteoarthritis
description	Objective: Temporomandibular joint (TMJ) osteoarthritis (OA) is a type of TMJ disorders with clinical symptoms of pain, movement limitation, cartilage degeneration and joint dysfunction. This review article is aiming to summarize recent findings on signaling pathways involved in TMJ OA development and progression. Methods: Most recent findings in TMJ OA studies have been reviewed and cited. Results: TMJ OA is caused by inflammation, abnormal mechanical loading and genetic abnormalities. The molecular mechanisms related to TMJ OA have been determined using different genetic mouse models. Recent studies demonstrated that several signaling pathways are involved in TMJ OA pathology, including Wnt/β-catenin, TGF-β and BMP, Indian Hedgehog, FGF, NF-κB, and Notch pathways, which are summarized in this review article. Alterations of these signaling pathways lead to the pathological changes in TMJ tissues, affecting cartilage matrix degradation, catabolic metabolism and chondrocyte apoptosis. Conclusion: Multiple signaling pathways were involved in the pathological process of TMJ OA. New therapeutic strategies, such as stem cell application, gene editing and other techniques may be utilized for TMJ OA treatment. The translational potential of this article: TMJ OA is a most important subtype of TMJ disorders and may lead to substantial joint pain, dysfunction, dental malocclusion, and reduced health-related quality of life. This review article summarized current findings of signaling pathways involved in TMJ OA, including Wnt/β-catenin, TGF-β and BMP, Indian Hedgehog, FGF, NF-κB, and Notch pathways, to better understand the pathological mechanisms of TMJ OA and define the molecular targets for TMJ OA treatment.
format	article
author	Ke Lu Feng Ma Dan Yi Huan Yu Liping Tong Di Chen
author_facet	Ke Lu Feng Ma Dan Yi Huan Yu Liping Tong Di Chen
author_sort	Ke Lu
title	Molecular signaling in temporomandibular joint osteoarthritis
title_short	Molecular signaling in temporomandibular joint osteoarthritis
title_full	Molecular signaling in temporomandibular joint osteoarthritis
title_fullStr	Molecular signaling in temporomandibular joint osteoarthritis
title_full_unstemmed	Molecular signaling in temporomandibular joint osteoarthritis
title_sort	molecular signaling in temporomandibular joint osteoarthritis
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/690717c417d04361afad61094381cf5c
work_keys_str_mv	AT kelu molecularsignalingintemporomandibularjointosteoarthritis AT fengma molecularsignalingintemporomandibularjointosteoarthritis AT danyi molecularsignalingintemporomandibularjointosteoarthritis AT huanyu molecularsignalingintemporomandibularjointosteoarthritis AT lipingtong molecularsignalingintemporomandibularjointosteoarthritis AT dichen molecularsignalingintemporomandibularjointosteoarthritis
_version_	1718408322582839296

Molecular signaling in temporomandibular joint osteoarthritis

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