Simultaneous bidirectional hindlimb locomotion in decerebrate cats

Abstract We show that epidural spinal cord stimulation can elicit stable bidirectional locomotion of decerebrate cats on a split-belt treadmill. The stepping pattern of one limb was similar to unidirectional forward walking and, the other—was similar to unidirectional backward walking. This confirms...

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Autores principales:	V. Lyakhovetskii, N. Merkulyeva, O. Gorskii, Pavel Musienko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6907ec4ffe6c4067b157b9808e715449
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spelling	oai:doaj.org-article:6907ec4ffe6c4067b157b9808e7154492021-12-02T14:06:49ZSimultaneous bidirectional hindlimb locomotion in decerebrate cats10.1038/s41598-021-82722-22045-2322https://doaj.org/article/6907ec4ffe6c4067b157b9808e7154492021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82722-2https://doaj.org/toc/2045-2322Abstract We show that epidural spinal cord stimulation can elicit stable bidirectional locomotion of decerebrate cats on a split-belt treadmill. The stepping pattern of one limb was similar to unidirectional forward walking and, the other—was similar to unidirectional backward walking. This confirms that spinal and brainstem circuitry are sufficient to control such complex and extraordinary motor tasks driven by somatosensory input. Interlimb coordination during forward and backward walking was preserved in 2 out of 4 animals during ‘extreme’ conditions when one of the treadmill belts was stopped. Bidirectional locomotion worsened but was still possible after temporary spinalization by cooling the spinal cord on a low thoracic level. These present evidence for the great degree of the automatism for this stepping mode defined by the spinal neuronal networks.V. LyakhovetskiiN. MerkulyevaO. GorskiiPavel MusienkoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q V. Lyakhovetskii N. Merkulyeva O. Gorskii Pavel Musienko Simultaneous bidirectional hindlimb locomotion in decerebrate cats
description	Abstract We show that epidural spinal cord stimulation can elicit stable bidirectional locomotion of decerebrate cats on a split-belt treadmill. The stepping pattern of one limb was similar to unidirectional forward walking and, the other—was similar to unidirectional backward walking. This confirms that spinal and brainstem circuitry are sufficient to control such complex and extraordinary motor tasks driven by somatosensory input. Interlimb coordination during forward and backward walking was preserved in 2 out of 4 animals during ‘extreme’ conditions when one of the treadmill belts was stopped. Bidirectional locomotion worsened but was still possible after temporary spinalization by cooling the spinal cord on a low thoracic level. These present evidence for the great degree of the automatism for this stepping mode defined by the spinal neuronal networks.
format	article
author	V. Lyakhovetskii N. Merkulyeva O. Gorskii Pavel Musienko
author_facet	V. Lyakhovetskii N. Merkulyeva O. Gorskii Pavel Musienko
author_sort	V. Lyakhovetskii
title	Simultaneous bidirectional hindlimb locomotion in decerebrate cats
title_short	Simultaneous bidirectional hindlimb locomotion in decerebrate cats
title_full	Simultaneous bidirectional hindlimb locomotion in decerebrate cats
title_fullStr	Simultaneous bidirectional hindlimb locomotion in decerebrate cats
title_full_unstemmed	Simultaneous bidirectional hindlimb locomotion in decerebrate cats
title_sort	simultaneous bidirectional hindlimb locomotion in decerebrate cats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6907ec4ffe6c4067b157b9808e715449
work_keys_str_mv	AT vlyakhovetskii simultaneousbidirectionalhindlimblocomotionindecerebratecats AT nmerkulyeva simultaneousbidirectionalhindlimblocomotionindecerebratecats AT ogorskii simultaneousbidirectionalhindlimblocomotionindecerebratecats AT pavelmusienko simultaneousbidirectionalhindlimblocomotionindecerebratecats
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Simultaneous bidirectional hindlimb locomotion in decerebrate cats

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