Survival of adults with acute lymphoblastic leukemia in Germany and the United States.

<h4>Background</h4>Adulthood acute lymphoblastic leukemia (ALL) is a rare disease. In contrast to childhood ALL, survival for adults with ALL is poor. Recently, new protocols, including use of pediatric protocols in young adults, have improved survival in clinical trials. Here, we examin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dianne Pulte, Lina Jansen, Adam Gondos, Alexander Katalinic, Benjamin Barnes, Meike Ressing, Bernd Holleczek, Andrea Eberle, Hermann Brenner, GEKID Cancer Survival Working Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/691019e186494f44baea4d5a41ae3981
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:691019e186494f44baea4d5a41ae3981
record_format	dspace
spelling	oai:doaj.org-article:691019e186494f44baea4d5a41ae39812021-11-18T08:35:47ZSurvival of adults with acute lymphoblastic leukemia in Germany and the United States.1932-620310.1371/journal.pone.0085554https://doaj.org/article/691019e186494f44baea4d5a41ae39812014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24475044/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Adulthood acute lymphoblastic leukemia (ALL) is a rare disease. In contrast to childhood ALL, survival for adults with ALL is poor. Recently, new protocols, including use of pediatric protocols in young adults, have improved survival in clinical trials. Here, we examine population level survival in Germany and the United States (US) to gain insight into the extent to which changes in clinical trials have translated into better survival on the population level.<h4>Methods</h4>Data were extracted from the Surveillance, Epidemiology, and End Results database in the US and 11 cancer registries in Germany. Patients age 15-69 diagnosed with ALL were included. Period analysis was used to estimate 5-year relative survival (RS).<h4>Results</h4>Overall 5-year RS was estimated at 43.4% for Germany and 35.5% for the US (p = 0.004), with a decrease in survival with increasing age. Survival was higher in Germany than the US for men (43.6% versus 37.7%, p = 0.002) but not for women (42.4% versus 40.3%, p>0.1). Five-year RS estimates increased in Germany and the US between 2002 and 2006 by 11.8 and 7.3 percent units, respectively (p = 0.02 and 0.04, respectively).<h4>Conclusions</h4>Survival for adults with ALL continues to be low compared with that for children, but a substantial increase in 5-year survival estimates was seen from 2002 to 2006 in both Germany and the US. The reasons for the survival differences between both countries require clarification.Dianne PulteLina JansenAdam GondosAlexander KatalinicBenjamin BarnesMeike RessingBernd HolleczekAndrea EberleHermann BrennerGEKID Cancer Survival Working GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85554 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dianne Pulte Lina Jansen Adam Gondos Alexander Katalinic Benjamin Barnes Meike Ressing Bernd Holleczek Andrea Eberle Hermann Brenner GEKID Cancer Survival Working Group Survival of adults with acute lymphoblastic leukemia in Germany and the United States.
description	<h4>Background</h4>Adulthood acute lymphoblastic leukemia (ALL) is a rare disease. In contrast to childhood ALL, survival for adults with ALL is poor. Recently, new protocols, including use of pediatric protocols in young adults, have improved survival in clinical trials. Here, we examine population level survival in Germany and the United States (US) to gain insight into the extent to which changes in clinical trials have translated into better survival on the population level.<h4>Methods</h4>Data were extracted from the Surveillance, Epidemiology, and End Results database in the US and 11 cancer registries in Germany. Patients age 15-69 diagnosed with ALL were included. Period analysis was used to estimate 5-year relative survival (RS).<h4>Results</h4>Overall 5-year RS was estimated at 43.4% for Germany and 35.5% for the US (p = 0.004), with a decrease in survival with increasing age. Survival was higher in Germany than the US for men (43.6% versus 37.7%, p = 0.002) but not for women (42.4% versus 40.3%, p>0.1). Five-year RS estimates increased in Germany and the US between 2002 and 2006 by 11.8 and 7.3 percent units, respectively (p = 0.02 and 0.04, respectively).<h4>Conclusions</h4>Survival for adults with ALL continues to be low compared with that for children, but a substantial increase in 5-year survival estimates was seen from 2002 to 2006 in both Germany and the US. The reasons for the survival differences between both countries require clarification.
format	article
author	Dianne Pulte Lina Jansen Adam Gondos Alexander Katalinic Benjamin Barnes Meike Ressing Bernd Holleczek Andrea Eberle Hermann Brenner GEKID Cancer Survival Working Group
author_facet	Dianne Pulte Lina Jansen Adam Gondos Alexander Katalinic Benjamin Barnes Meike Ressing Bernd Holleczek Andrea Eberle Hermann Brenner GEKID Cancer Survival Working Group
author_sort	Dianne Pulte
title	Survival of adults with acute lymphoblastic leukemia in Germany and the United States.
title_short	Survival of adults with acute lymphoblastic leukemia in Germany and the United States.
title_full	Survival of adults with acute lymphoblastic leukemia in Germany and the United States.
title_fullStr	Survival of adults with acute lymphoblastic leukemia in Germany and the United States.
title_full_unstemmed	Survival of adults with acute lymphoblastic leukemia in Germany and the United States.
title_sort	survival of adults with acute lymphoblastic leukemia in germany and the united states.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/691019e186494f44baea4d5a41ae3981
work_keys_str_mv	AT diannepulte survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT linajansen survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT adamgondos survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT alexanderkatalinic survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT benjaminbarnes survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT meikeressing survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT berndholleczek survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT andreaeberle survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT hermannbrenner survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates AT gekidcancersurvivalworkinggroup survivalofadultswithacutelymphoblasticleukemiaingermanyandtheunitedstates
_version_	1718421564802727936

Survival of adults with acute lymphoblastic leukemia in Germany and the United States.

Ejemplares similares