A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis

Qiaolin Wang,1– 3 Chengzhi Lv,4 Xi Han,5 Minxue Shen,1– 3,6 Yehong Kuang1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan, People’s R...

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Autores principales:	Wang Q, Lv C, Han X, Shen M, Kuang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	covid-19 sars-cov-2 vaccine unvaccination psoriasis safety adverse reaction Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/69141e740a184ff0a434058884fd9aa8
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spelling	oai:doaj.org-article:69141e740a184ff0a434058884fd9aa82021-11-28T19:13:10ZA Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis1178-7031https://doaj.org/article/69141e740a184ff0a434058884fd9aa82021-11-01T00:00:00Zhttps://www.dovepress.com/a-web-based-survey-on-factors-for-unvaccination-and-adverse-reactions--peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Qiaolin Wang,1– 3 Chengzhi Lv,4 Xi Han,5 Minxue Shen,1– 3,6 Yehong Kuang1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan, People’s Republic of China; 3Hunan Engineering Research Center of Skin Health and Disease; Hunan Key Laboratory of Skin Cancer and Psoriasis (Xiangya Hospital), Changsha, Hunan, People’s Republic of China; 4Department of Psoriasis, Dalian Dermatosis Hospital, Dalian, Liaoning, People’s Republic of China; 5ULink College Guangzhou, Guangzhou, Guangdong, People’s Republic of China; 6Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Minxue ShenDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, 87 Xiangya Road, Changsha, Hunan, People’s Republic of ChinaEmail shenmx1988@csu.edu.cnYehong KuangDepartment of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, People’s Republic of ChinaEmail yh_927@126.comPurpose: Vaccination is one of the most important strategy to prevent infections and control epidemics, but it also raises concerns about safety in patients receiving treatments. This study aimed to investigate the rate and factors for unvaccination, as well as adverse reactions and deterioration of disease after SARS-CoV-2 vaccination in psoriatic patients.Methods: A web-based questionnaire survey on SARS-CoV-2 vaccination, adverse reactions, and self-reported change of disease condition after vaccination in patients with psoriasis was conducted. Demographic, clinical, and psychological data were collected. Multivariable logistic regression was used in the estimation of associations.Results: A total of 788 psoriatic patients were investigated, and 68.9% reported SARS-CoV-2 vaccination. Younger age, use of interleukin-17 inhibitors, and symptoms of anxiety were associated with unvaccination. The incidence of overall adverse reactions after vaccination was 30.8%, and no severe adverse reaction was reported. The most common local and systemic adverse reactions were pain at the injection site and fatigue, respectively. Most patients reported no change in psoriasis after vaccination, while 16.6% and 4.4% reported slight and significant deteriorations of the disease, respectively. Nonadherence to treatment, symptoms of anxiety and depression, and perceived stress were associated with self-reported deterioration of psoriasis after vaccination.Conclusion: While a favorable safety profile of SARS-CoV-2 vaccines is observed, receiving biologic treatment is factor for unvaccination in patients with psoriasis. Deterioration of psoriasis reported by a small proportion of patients is partially attributable to mental and behavioral factors.Keywords: COVID-19, SARS-CoV-2, vaccine, unvaccination, psoriasis, safety, adverse reactionWang QLv CHan XShen MKuang YDove Medical Pressarticlecovid-19sars-cov-2vaccineunvaccinationpsoriasissafetyadverse reactionPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 6265-6273 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 sars-cov-2 vaccine unvaccination psoriasis safety adverse reaction Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	covid-19 sars-cov-2 vaccine unvaccination psoriasis safety adverse reaction Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Wang Q Lv C Han X Shen M Kuang Y A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis
description	Qiaolin Wang,1– 3 Chengzhi Lv,4 Xi Han,5 Minxue Shen,1– 3,6 Yehong Kuang1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan, People’s Republic of China; 3Hunan Engineering Research Center of Skin Health and Disease; Hunan Key Laboratory of Skin Cancer and Psoriasis (Xiangya Hospital), Changsha, Hunan, People’s Republic of China; 4Department of Psoriasis, Dalian Dermatosis Hospital, Dalian, Liaoning, People’s Republic of China; 5ULink College Guangzhou, Guangzhou, Guangdong, People’s Republic of China; 6Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Minxue ShenDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, 87 Xiangya Road, Changsha, Hunan, People’s Republic of ChinaEmail shenmx1988@csu.edu.cnYehong KuangDepartment of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, People’s Republic of ChinaEmail yh_927@126.comPurpose: Vaccination is one of the most important strategy to prevent infections and control epidemics, but it also raises concerns about safety in patients receiving treatments. This study aimed to investigate the rate and factors for unvaccination, as well as adverse reactions and deterioration of disease after SARS-CoV-2 vaccination in psoriatic patients.Methods: A web-based questionnaire survey on SARS-CoV-2 vaccination, adverse reactions, and self-reported change of disease condition after vaccination in patients with psoriasis was conducted. Demographic, clinical, and psychological data were collected. Multivariable logistic regression was used in the estimation of associations.Results: A total of 788 psoriatic patients were investigated, and 68.9% reported SARS-CoV-2 vaccination. Younger age, use of interleukin-17 inhibitors, and symptoms of anxiety were associated with unvaccination. The incidence of overall adverse reactions after vaccination was 30.8%, and no severe adverse reaction was reported. The most common local and systemic adverse reactions were pain at the injection site and fatigue, respectively. Most patients reported no change in psoriasis after vaccination, while 16.6% and 4.4% reported slight and significant deteriorations of the disease, respectively. Nonadherence to treatment, symptoms of anxiety and depression, and perceived stress were associated with self-reported deterioration of psoriasis after vaccination.Conclusion: While a favorable safety profile of SARS-CoV-2 vaccines is observed, receiving biologic treatment is factor for unvaccination in patients with psoriasis. Deterioration of psoriasis reported by a small proportion of patients is partially attributable to mental and behavioral factors.Keywords: COVID-19, SARS-CoV-2, vaccine, unvaccination, psoriasis, safety, adverse reaction
format	article
author	Wang Q Lv C Han X Shen M Kuang Y
author_facet	Wang Q Lv C Han X Shen M Kuang Y
author_sort	Wang Q
title	A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis
title_short	A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis
title_full	A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis
title_fullStr	A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis
title_full_unstemmed	A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis
title_sort	web-based survey on factors for unvaccination and adverse reactions of sars-cov-2 vaccines in chinese patients with psoriasis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/69141e740a184ff0a434058884fd9aa8
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A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis

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