Pulse sharpness as a quantitative index of vascular aging

Abstract The aim of this study was to develop a robust algorithm to quantify pulse sharpness that can complement the limitations of radial augmentation index (rAIx) and explore the role of this quantitative sharpness index in reflecting vascular aging or arterial stiffness. The pulse sharpness index...

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Autores principales:	Jang-Han Bae, Young Ju Jeon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6917aa286d6b4a7487c6b4862c1db63e
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spelling	oai:doaj.org-article:6917aa286d6b4a7487c6b4862c1db63e2021-12-02T18:37:12ZPulse sharpness as a quantitative index of vascular aging10.1038/s41598-021-99315-82045-2322https://doaj.org/article/6917aa286d6b4a7487c6b4862c1db63e2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99315-8https://doaj.org/toc/2045-2322Abstract The aim of this study was to develop a robust algorithm to quantify pulse sharpness that can complement the limitations of radial augmentation index (rAIx) and explore the role of this quantitative sharpness index in reflecting vascular aging or arterial stiffness. The pulse sharpness index (PSI) was developed by combining the end point angle and virtual height, and 528 radial pulses were analyzed. The PSI could be uniformly applied to various waveform morphologies, even those with no or vague tidal waves, unlike the rAIx. Significant sex differences were identified in the rAIx and PSI (P < 0.01 for both), and significant age-dependent decreases in the PSI were observed (P < 0.01). In addition, the PSI and age were correlated (r = − 0.550) at least as strong as the rAIx and age (r = 0.532), and the PSI had a significant negative correlation with arterial stiffness (r = − 0.700). Furthermore, the multiple linear regression model for arterial stiffness using the PSI, age, sex and heart rate showed the excellent performance (cross-validated R2 = 0.701), and the PSI was found to have the greatest influence on arterial stiffness. This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx.Jang-Han BaeYoung Ju JeonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jang-Han Bae Young Ju Jeon Pulse sharpness as a quantitative index of vascular aging
description	Abstract The aim of this study was to develop a robust algorithm to quantify pulse sharpness that can complement the limitations of radial augmentation index (rAIx) and explore the role of this quantitative sharpness index in reflecting vascular aging or arterial stiffness. The pulse sharpness index (PSI) was developed by combining the end point angle and virtual height, and 528 radial pulses were analyzed. The PSI could be uniformly applied to various waveform morphologies, even those with no or vague tidal waves, unlike the rAIx. Significant sex differences were identified in the rAIx and PSI (P < 0.01 for both), and significant age-dependent decreases in the PSI were observed (P < 0.01). In addition, the PSI and age were correlated (r = − 0.550) at least as strong as the rAIx and age (r = 0.532), and the PSI had a significant negative correlation with arterial stiffness (r = − 0.700). Furthermore, the multiple linear regression model for arterial stiffness using the PSI, age, sex and heart rate showed the excellent performance (cross-validated R2 = 0.701), and the PSI was found to have the greatest influence on arterial stiffness. This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx.
format	article
author	Jang-Han Bae Young Ju Jeon
author_facet	Jang-Han Bae Young Ju Jeon
author_sort	Jang-Han Bae
title	Pulse sharpness as a quantitative index of vascular aging
title_short	Pulse sharpness as a quantitative index of vascular aging
title_full	Pulse sharpness as a quantitative index of vascular aging
title_fullStr	Pulse sharpness as a quantitative index of vascular aging
title_full_unstemmed	Pulse sharpness as a quantitative index of vascular aging
title_sort	pulse sharpness as a quantitative index of vascular aging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6917aa286d6b4a7487c6b4862c1db63e
work_keys_str_mv	AT janghanbae pulsesharpnessasaquantitativeindexofvascularaging AT youngjujeon pulsesharpnessasaquantitativeindexofvascularaging
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Pulse sharpness as a quantitative index of vascular aging

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