Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells

Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells

Abstract The non-canonical initiation factors DENR and MCTS1 have been linked to cancer and autism. We recently showed in Drosophila that DENR and MCTS1 regulate translation re-initiation on transcripts containing upstream Open Reading Frames (uORFs) with strong Kozak sequences (stuORFs). Due to the...

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Autores principales: Sibylle Schleich, Julieta M. Acevedo, Katharina Clemm von Hohenberg, Aurelio A. Teleman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/69183d83402344d889beea0fb8e0e47d
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