Tauopathy and cognitive impairment in experimental diabetes mellitus

Currently, diabetes mellitus (DM) is the most common metabolic disorder, which is manifested by hyperglycemia and leads to vascular and cognitive impairment. Mechanisms of cognitive dysfunction in patients with DM remain highly unclear, thus complicating the search for effective strategies for the p...

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Autores principales:	Mariia V. Matveeva, Yulia G. SamoiIova, Natalia G. Zhukova, Oksana A. Oleynik, Maria A. Rotkank
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	diabetes mellitus type 1 cognitive impairment tau protein alzheimer's disease Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/6921b8907daf436097a27b7b96e31b92
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spelling	oai:doaj.org-article:6921b8907daf436097a27b7b96e31b922021-11-14T09:00:21ZTauopathy and cognitive impairment in experimental diabetes mellitus2072-03512072-037810.14341/2072-0351-5842https://doaj.org/article/6921b8907daf436097a27b7b96e31b922017-08-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8282https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Currently, diabetes mellitus (DM) is the most common metabolic disorder, which is manifested by hyperglycemia and leads to vascular and cognitive impairment. Mechanisms of cognitive dysfunction in patients with DM remain highly unclear, thus complicating the search for effective strategies for the prevention and treatment of dementia. Recently, scientists have discussed the issues regarding the relationship between DM and Alzheimer’s disease (AD), such as risk factors that trigger the cascade of pathological reactions. Patients with DM show an increased risk of developing AD. Similarly, patients with AD have been shown to have impaired insulin and glucose metabolism. Both these diseases have common nosology, pathology and biochemical basics, including oxidative stress, formation of advanced glycation end products, dysregulation of glucose metabolism and altered insulin signaling pathways. The microtubule-associated tau protein is involved in one of the causative mechanisms underlying the development of AD. We provide an overview of the major domestic and foreign data analyses regarding tau protein and the development of cognitive disorders in experimental DM.Mariia V. MatveevaYulia G. SamoiIovaNatalia G. ZhukovaOksana A. OleynikMaria A. RotkankEndocrinology Research Centrearticlediabetes mellitus type 1cognitive impairmenttau proteinalzheimer's diseaseNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 3, Pp 181-184 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 1 cognitive impairment tau protein alzheimer's disease Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 1 cognitive impairment tau protein alzheimer's disease Nutritional diseases. Deficiency diseases RC620-627 Mariia V. Matveeva Yulia G. SamoiIova Natalia G. Zhukova Oksana A. Oleynik Maria A. Rotkank Tauopathy and cognitive impairment in experimental diabetes mellitus
description	Currently, diabetes mellitus (DM) is the most common metabolic disorder, which is manifested by hyperglycemia and leads to vascular and cognitive impairment. Mechanisms of cognitive dysfunction in patients with DM remain highly unclear, thus complicating the search for effective strategies for the prevention and treatment of dementia. Recently, scientists have discussed the issues regarding the relationship between DM and Alzheimer’s disease (AD), such as risk factors that trigger the cascade of pathological reactions. Patients with DM show an increased risk of developing AD. Similarly, patients with AD have been shown to have impaired insulin and glucose metabolism. Both these diseases have common nosology, pathology and biochemical basics, including oxidative stress, formation of advanced glycation end products, dysregulation of glucose metabolism and altered insulin signaling pathways. The microtubule-associated tau protein is involved in one of the causative mechanisms underlying the development of AD. We provide an overview of the major domestic and foreign data analyses regarding tau protein and the development of cognitive disorders in experimental DM.
format	article
author	Mariia V. Matveeva Yulia G. SamoiIova Natalia G. Zhukova Oksana A. Oleynik Maria A. Rotkank
author_facet	Mariia V. Matveeva Yulia G. SamoiIova Natalia G. Zhukova Oksana A. Oleynik Maria A. Rotkank
author_sort	Mariia V. Matveeva
title	Tauopathy and cognitive impairment in experimental diabetes mellitus
title_short	Tauopathy and cognitive impairment in experimental diabetes mellitus
title_full	Tauopathy and cognitive impairment in experimental diabetes mellitus
title_fullStr	Tauopathy and cognitive impairment in experimental diabetes mellitus
title_full_unstemmed	Tauopathy and cognitive impairment in experimental diabetes mellitus
title_sort	tauopathy and cognitive impairment in experimental diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/6921b8907daf436097a27b7b96e31b92
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Tauopathy and cognitive impairment in experimental diabetes mellitus

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