Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?

Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?

Thomas HügleDepartment of Rheumatology, Felix-Platter-Spital, University of Basel, Basel, SwitzerlandAbstract: Interstitial lung disease (ILD) and lung fibrosis are characterized by different grades of fibrosis and inflammation. Persistent low-grade inflammation is believed to play a ma...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Thomas Hügle
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2011
Materias:
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/69247a08a1454f35987cc8202fa1a042
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:69247a08a1454f35987cc8202fa1a042
record_format dspace
spelling oai:doaj.org-article:69247a08a1454f35987cc8202fa1a0422021-12-02T04:22:24ZImmunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?1178-7031https://doaj.org/article/69247a08a1454f35987cc8202fa1a0422011-02-01T00:00:00Zhttp://www.dovepress.com/immunology-of-fibrotic-lung-disease-managing-infections-whilst-prevent-a6209https://doaj.org/toc/1178-7031Thomas HügleDepartment of Rheumatology, Felix-Platter-Spital, University of Basel, Basel, SwitzerlandAbstract: Interstitial lung disease (ILD) and lung fibrosis are characterized by different grades of fibrosis and inflammation. Persistent low-grade inflammation is believed to play a major pathogenic role, leading to an imbalance of cytokines, growth factors, and tissue proteinases. Recruited monocytes and macrophages play a pivotal role through their cytokine expression and possibly differentiation into fibrocytes, pericytes, or myofibroblasts. Atypical bacterial infections can cause ILD, although not usually in the form of usual interstitial pneumonia. On the other hand, bacterial colonization is frequently encountered in patients with chronic fibrotic lung disorders, and patients regularly undergo antibacterial treatment. As demonstrated in patients with diffuse panbronchiolitis and other chronic respiratory disorders, treatment with macrolides can be beneficial. This is partly explained by their antimicrobial effects but, for macrolides, immunomodulatory properties have been identified which might also be beneficial in patients with ILD or lung fibrosis. This article reviews the immunology of lung fibrogenesis and putative implications of macrolides for reinstallation of tolerance.Keywords: lung fibrosis, inflammation, pneumonia Thomas HügleDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2011, Iss default, Pp 21-27 (2011)
institution DOAJ
collection DOAJ
language EN
topic Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
spellingShingle Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Thomas Hügle
Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?
description Thomas HügleDepartment of Rheumatology, Felix-Platter-Spital, University of Basel, Basel, SwitzerlandAbstract: Interstitial lung disease (ILD) and lung fibrosis are characterized by different grades of fibrosis and inflammation. Persistent low-grade inflammation is believed to play a major pathogenic role, leading to an imbalance of cytokines, growth factors, and tissue proteinases. Recruited monocytes and macrophages play a pivotal role through their cytokine expression and possibly differentiation into fibrocytes, pericytes, or myofibroblasts. Atypical bacterial infections can cause ILD, although not usually in the form of usual interstitial pneumonia. On the other hand, bacterial colonization is frequently encountered in patients with chronic fibrotic lung disorders, and patients regularly undergo antibacterial treatment. As demonstrated in patients with diffuse panbronchiolitis and other chronic respiratory disorders, treatment with macrolides can be beneficial. This is partly explained by their antimicrobial effects but, for macrolides, immunomodulatory properties have been identified which might also be beneficial in patients with ILD or lung fibrosis. This article reviews the immunology of lung fibrogenesis and putative implications of macrolides for reinstallation of tolerance.Keywords: lung fibrosis, inflammation, pneumonia
format article
author Thomas Hügle
author_facet Thomas Hügle
author_sort Thomas Hügle
title Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?
title_short Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?
title_full Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?
title_fullStr Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?
title_full_unstemmed Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?
title_sort immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?
publisher Dove Medical Press
publishDate 2011
url https://doaj.org/article/69247a08a1454f35987cc8202fa1a042
work_keys_str_mv AT thomashampuumlgle immunologyoffibroticlungdiseasemanaginginfectionswhilstpreventingautoimmunity
_version_ 1718401251473883136

Ejemplares similares