Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of <italic toggle="yes">Candida albicans</italic> Filamentation

Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of <italic toggle="yes">Candida albicans</italic> Filamentation

ABSTRACT Candida albicans remains the main etiologic agent of candidiasis, the most common fungal infection and now the third most frequent infection in U.S. hospitals. The scarcity of antifungal agents and their limited efficacy contribute to the unacceptably high morbidity and mortality rates asso...

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Autores principales: Jesus A. Romo, Christopher G. Pierce, Ashok K. Chaturvedi, Anna L. Lazzell, Stanton F. McHardy, Stephen P. Saville, Jose L. Lopez-Ribot
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Candida albicans
anti-virulence factor
antifungal drugs
filamentation
large-scale phenotypic screening
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/69248be2b72a44429a21da8645afd8de
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