TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

TAGAP gene variants are linked to human autoimmunity. Here the authors identify TAGAP as a Dectin-1 and EphB2-binding protein mediating antifungal innate immune signaling and cytokine production, and demonstrate TAGAP in non-T cells promotes Th17 response in mouse models of infection and autoimmunit...

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Autores principales: Jianwen Chen, Ruirui He, Wanwei Sun, Ru Gao, Qianwen Peng, Liwen Zhu, Yanyun Du, Xiaojian Ma, Xiaoli Guo, Huazhi Zhang, Chengcheng Tan, Junhan Wang, Wei Zhang, Xiufang Weng, Jianghong Man, Hermann Bauer, Qing K. Wang, Bradley N. Martin, Cun-Jin Zhang, Xiaoxia Li, Chenhui Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/69258493889b41e28feb66c907a43116
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Sumario:TAGAP gene variants are linked to human autoimmunity. Here the authors identify TAGAP as a Dectin-1 and EphB2-binding protein mediating antifungal innate immune signaling and cytokine production, and demonstrate TAGAP in non-T cells promotes Th17 response in mouse models of infection and autoimmunity.

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