TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

TAGAP gene variants are linked to human autoimmunity. Here the authors identify TAGAP as a Dectin-1 and EphB2-binding protein mediating antifungal innate immune signaling and cytokine production, and demonstrate TAGAP in non-T cells promotes Th17 response in mouse models of infection and autoimmunit...

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Autores principales: Jianwen Chen, Ruirui He, Wanwei Sun, Ru Gao, Qianwen Peng, Liwen Zhu, Yanyun Du, Xiaojian Ma, Xiaoli Guo, Huazhi Zhang, Chengcheng Tan, Junhan Wang, Wei Zhang, Xiufang Weng, Jianghong Man, Hermann Bauer, Qing K. Wang, Bradley N. Martin, Cun-Jin Zhang, Xiaoxia Li, Chenhui Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/69258493889b41e28feb66c907a43116
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spelling oai:doaj.org-article:69258493889b41e28feb66c907a431162021-12-02T14:41:02ZTAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response10.1038/s41467-020-15564-72041-1723https://doaj.org/article/69258493889b41e28feb66c907a431162020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15564-7https://doaj.org/toc/2041-1723TAGAP gene variants are linked to human autoimmunity. Here the authors identify TAGAP as a Dectin-1 and EphB2-binding protein mediating antifungal innate immune signaling and cytokine production, and demonstrate TAGAP in non-T cells promotes Th17 response in mouse models of infection and autoimmunity.Jianwen ChenRuirui HeWanwei SunRu GaoQianwen PengLiwen ZhuYanyun DuXiaojian MaXiaoli GuoHuazhi ZhangChengcheng TanJunhan WangWei ZhangXiufang WengJianghong ManHermann BauerQing K. WangBradley N. MartinCun-Jin ZhangXiaoxia LiChenhui WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jianwen Chen
Ruirui He
Wanwei Sun
Ru Gao
Qianwen Peng
Liwen Zhu
Yanyun Du
Xiaojian Ma
Xiaoli Guo
Huazhi Zhang
Chengcheng Tan
Junhan Wang
Wei Zhang
Xiufang Weng
Jianghong Man
Hermann Bauer
Qing K. Wang
Bradley N. Martin
Cun-Jin Zhang
Xiaoxia Li
Chenhui Wang
TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response
description TAGAP gene variants are linked to human autoimmunity. Here the authors identify TAGAP as a Dectin-1 and EphB2-binding protein mediating antifungal innate immune signaling and cytokine production, and demonstrate TAGAP in non-T cells promotes Th17 response in mouse models of infection and autoimmunity.
format article
author Jianwen Chen
Ruirui He
Wanwei Sun
Ru Gao
Qianwen Peng
Liwen Zhu
Yanyun Du
Xiaojian Ma
Xiaoli Guo
Huazhi Zhang
Chengcheng Tan
Junhan Wang
Wei Zhang
Xiufang Weng
Jianghong Man
Hermann Bauer
Qing K. Wang
Bradley N. Martin
Cun-Jin Zhang
Xiaoxia Li
Chenhui Wang
author_facet Jianwen Chen
Ruirui He
Wanwei Sun
Ru Gao
Qianwen Peng
Liwen Zhu
Yanyun Du
Xiaojian Ma
Xiaoli Guo
Huazhi Zhang
Chengcheng Tan
Junhan Wang
Wei Zhang
Xiufang Weng
Jianghong Man
Hermann Bauer
Qing K. Wang
Bradley N. Martin
Cun-Jin Zhang
Xiaoxia Li
Chenhui Wang
author_sort Jianwen Chen
title TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response
title_short TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response
title_full TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response
title_fullStr TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response
title_full_unstemmed TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response
title_sort tagap instructs th17 differentiation by bridging dectin activation to ephb2 signaling in innate antifungal response
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/69258493889b41e28feb66c907a43116
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