Clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes

Karen Barnard1,2, Mary Elizabeth Cox1, Jennifer B Green1,21Department of Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Duke University Medical Center, Durham, NC, USA; 2Department of Medicine, Division of Endocrinology, Durham Veterans Affairs Medical Center, Durham, NC, U...

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Autores principales: Karen Barnard, Mary Elizabeth Cox, Jennifer B Green
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Lenguaje:EN
Publicado: Dove Medical Press 2010
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Acceso en línea:https://doaj.org/article/6927147c9be3449c808246b19776356e
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spelling oai:doaj.org-article:6927147c9be3449c808246b19776356e2021-12-02T01:30:14ZClinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes1178-7007https://doaj.org/article/6927147c9be3449c808246b19776356e2010-10-01T00:00:00Zhttp://www.dovepress.com/clinical-utility-of-fixed-combinations-of-sitagliptinndashmetformin-in-a5548https://doaj.org/toc/1178-7007Karen Barnard1,2, Mary Elizabeth Cox1, Jennifer B Green1,21Department of Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Duke University Medical Center, Durham, NC, USA; 2Department of Medicine, Division of Endocrinology, Durham Veterans Affairs Medical Center, Durham, NC, USAAbstract: Adequate glycemic control in type 2 diabetes remains a difficult but achievable goal. The development of new classes of glucose-lowering medications, including in particular the incretin-based therapies, provides an opportunity to utilize combinations of medications which target multiple physiologic abnormalities in type 2 diabetes. Complementary combination therapy with sitagliptin–metformin lowers glucose via enhancement of insulin secretion, suppression of glucagon secretion, and insulin sensitization. Use of this combination in diabetes management will provide a greater degree of glycosylated hemoglobin-lowering than that seen with the use of either drug as monotherapy, is unlikely to cause significant hypoglycemia, and is generally associated with weight loss. The effectiveness, tolerability, and potential cost savings associated with the use of sitagliptin–metformin combination therapy make this an attractive option in diabetes management. The possible beneficial effects of this therapy on beta cell function, as well as its cardiovascular impact, remain inadequately explored but are of significant interest.Keywords: diabetes mellitus, sitagliptin, dipeptidyl peptidase-4, combination therapy Karen BarnardMary Elizabeth CoxJennifer B GreenDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2010, Iss default, Pp 363-372 (2010)
institution DOAJ
collection DOAJ
language EN
topic Specialties of internal medicine
RC581-951
spellingShingle Specialties of internal medicine
RC581-951
Karen Barnard
Mary Elizabeth Cox
Jennifer B Green
Clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes
description Karen Barnard1,2, Mary Elizabeth Cox1, Jennifer B Green1,21Department of Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Duke University Medical Center, Durham, NC, USA; 2Department of Medicine, Division of Endocrinology, Durham Veterans Affairs Medical Center, Durham, NC, USAAbstract: Adequate glycemic control in type 2 diabetes remains a difficult but achievable goal. The development of new classes of glucose-lowering medications, including in particular the incretin-based therapies, provides an opportunity to utilize combinations of medications which target multiple physiologic abnormalities in type 2 diabetes. Complementary combination therapy with sitagliptin–metformin lowers glucose via enhancement of insulin secretion, suppression of glucagon secretion, and insulin sensitization. Use of this combination in diabetes management will provide a greater degree of glycosylated hemoglobin-lowering than that seen with the use of either drug as monotherapy, is unlikely to cause significant hypoglycemia, and is generally associated with weight loss. The effectiveness, tolerability, and potential cost savings associated with the use of sitagliptin–metformin combination therapy make this an attractive option in diabetes management. The possible beneficial effects of this therapy on beta cell function, as well as its cardiovascular impact, remain inadequately explored but are of significant interest.Keywords: diabetes mellitus, sitagliptin, dipeptidyl peptidase-4, combination therapy
format article
author Karen Barnard
Mary Elizabeth Cox
Jennifer B Green
author_facet Karen Barnard
Mary Elizabeth Cox
Jennifer B Green
author_sort Karen Barnard
title Clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes
title_short Clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes
title_full Clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes
title_fullStr Clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes
title_full_unstemmed Clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes
title_sort clinical utility of fixed combinations of sitagliptin–metformin in treatment of type 2 diabetes
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/6927147c9be3449c808246b19776356e
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AT maryelizabethcox clinicalutilityoffixedcombinationsofsitagliptinampndashmetforminintreatmentoftype2diabetes
AT jenniferbgreen clinicalutilityoffixedcombinationsofsitagliptinampndashmetforminintreatmentoftype2diabetes
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