Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI<25 Kg/m²) compared to obese...
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Formato: | article |
Lenguaje: | EN |
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Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/69278706f1ba4c3e8b31e43c60a600aa |
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