Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.

<h4>Background</h4>Congenital sensorineural deafness is an inherited condition found in many dog breeds, including Australian Stumpy-tail Cattle Dogs (ASCD). This deafness is evident in young pups and may affect one ear (unilateral) or both ears (bilateral). The genetic locus/loci involv...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Susan Sommerlad, Allan F McRae, Brenda McDonald, Isobel Johnstone, Leigh Cuttell, Jennifer M Seddon, Caroline A O'Leary
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
R
Q
Acceso en línea:https://doaj.org/article/692a134fd13749d896d37f9c699b28c2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:692a134fd13749d896d37f9c699b28c2
record_format dspace
spelling oai:doaj.org-article:692a134fd13749d896d37f9c699b28c22021-11-18T07:03:25ZCongenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.1932-620310.1371/journal.pone.0013364https://doaj.org/article/692a134fd13749d896d37f9c699b28c22010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20967282/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Congenital sensorineural deafness is an inherited condition found in many dog breeds, including Australian Stumpy-tail Cattle Dogs (ASCD). This deafness is evident in young pups and may affect one ear (unilateral) or both ears (bilateral). The genetic locus/loci involved is unknown for all dog breeds. The aims of this study were to determine incidence, inheritance mechanism, and possible association of congenital sensorineural deafness with coat colour in ASCD and to identify the genetic locus underpinning this disease.<h4>Methodology/principal findings</h4>A total of 315 ASCD were tested for sensorineural deafness using the brain stem auditory evoked response (BAER) test. Disease penetrance was estimated directly, using the ratio of unilaterally to bilaterally deaf dogs, and segregation analysis was performed using Mendel. A complete genome screen was undertaken using 325 microsatellites spread throughout the genome, on a pedigree of 50 BAER tested ASCD in which deafness was segregating. Fifty-six dogs (17.8%) were deaf, with 17 bilaterally and 39 unilaterally deaf. Unilaterally deaf dogs showed no significant left/right bias (p = 0.19) and no significant difference was observed in frequencies between the sexes (p = 0.18). Penetrance of deafness was estimated as 0.72. Testing the association of red/blue coat colour and deafness without accounting for pedigree structure showed that red dogs were 1.8 times more likely to be deaf (p = 0.045). The within family association between red/blue coat colour and deafness was strongly significant (p = 0.00036), with red coat colour segregating more frequently with deafness (COR = 0.48). The relationship between deafness and coat speckling approached significance (p = 0.07), with the lack of statistical significance possibly due to only four families co-segregating for both deafness and speckling. The deafness phenotype was mapped to CFA10 (maximum linkage peak on CFA10 -log10 p-value = 3.64), as was both coat colour and speckling. Fine mapping was then performed on 45 of these 50 dogs and a further 48 dogs (n = 93). Sequencing candidate gene Sox10 in 6 hearing ASCD, 2 unilaterally deaf ASCD and 2 bilaterally deaf ASCD did not reveal any disease-associated mutations.<h4>Conclusions</h4>Deafness in ASCD is an incompletely penetrant autosomal recessive inherited disease that maps to CFA10.Susan SommerladAllan F McRaeBrenda McDonaldIsobel JohnstoneLeigh CuttellJennifer M SeddonCaroline A O'LearyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13364 (2010)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Susan Sommerlad
Allan F McRae
Brenda McDonald
Isobel Johnstone
Leigh Cuttell
Jennifer M Seddon
Caroline A O'Leary
Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.
description <h4>Background</h4>Congenital sensorineural deafness is an inherited condition found in many dog breeds, including Australian Stumpy-tail Cattle Dogs (ASCD). This deafness is evident in young pups and may affect one ear (unilateral) or both ears (bilateral). The genetic locus/loci involved is unknown for all dog breeds. The aims of this study were to determine incidence, inheritance mechanism, and possible association of congenital sensorineural deafness with coat colour in ASCD and to identify the genetic locus underpinning this disease.<h4>Methodology/principal findings</h4>A total of 315 ASCD were tested for sensorineural deafness using the brain stem auditory evoked response (BAER) test. Disease penetrance was estimated directly, using the ratio of unilaterally to bilaterally deaf dogs, and segregation analysis was performed using Mendel. A complete genome screen was undertaken using 325 microsatellites spread throughout the genome, on a pedigree of 50 BAER tested ASCD in which deafness was segregating. Fifty-six dogs (17.8%) were deaf, with 17 bilaterally and 39 unilaterally deaf. Unilaterally deaf dogs showed no significant left/right bias (p = 0.19) and no significant difference was observed in frequencies between the sexes (p = 0.18). Penetrance of deafness was estimated as 0.72. Testing the association of red/blue coat colour and deafness without accounting for pedigree structure showed that red dogs were 1.8 times more likely to be deaf (p = 0.045). The within family association between red/blue coat colour and deafness was strongly significant (p = 0.00036), with red coat colour segregating more frequently with deafness (COR = 0.48). The relationship between deafness and coat speckling approached significance (p = 0.07), with the lack of statistical significance possibly due to only four families co-segregating for both deafness and speckling. The deafness phenotype was mapped to CFA10 (maximum linkage peak on CFA10 -log10 p-value = 3.64), as was both coat colour and speckling. Fine mapping was then performed on 45 of these 50 dogs and a further 48 dogs (n = 93). Sequencing candidate gene Sox10 in 6 hearing ASCD, 2 unilaterally deaf ASCD and 2 bilaterally deaf ASCD did not reveal any disease-associated mutations.<h4>Conclusions</h4>Deafness in ASCD is an incompletely penetrant autosomal recessive inherited disease that maps to CFA10.
format article
author Susan Sommerlad
Allan F McRae
Brenda McDonald
Isobel Johnstone
Leigh Cuttell
Jennifer M Seddon
Caroline A O'Leary
author_facet Susan Sommerlad
Allan F McRae
Brenda McDonald
Isobel Johnstone
Leigh Cuttell
Jennifer M Seddon
Caroline A O'Leary
author_sort Susan Sommerlad
title Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.
title_short Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.
title_full Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.
title_fullStr Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.
title_full_unstemmed Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10.
title_sort congenital sensorineural deafness in australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to cfa10.
publisher Public Library of Science (PLoS)
publishDate 2010
url https://doaj.org/article/692a134fd13749d896d37f9c699b28c2
work_keys_str_mv AT susansommerlad congenitalsensorineuraldeafnessinaustralianstumpytailcattledogsisanautosomalrecessivetraitthatmapstocfa10
AT allanfmcrae congenitalsensorineuraldeafnessinaustralianstumpytailcattledogsisanautosomalrecessivetraitthatmapstocfa10
AT brendamcdonald congenitalsensorineuraldeafnessinaustralianstumpytailcattledogsisanautosomalrecessivetraitthatmapstocfa10
AT isobeljohnstone congenitalsensorineuraldeafnessinaustralianstumpytailcattledogsisanautosomalrecessivetraitthatmapstocfa10
AT leighcuttell congenitalsensorineuraldeafnessinaustralianstumpytailcattledogsisanautosomalrecessivetraitthatmapstocfa10
AT jennifermseddon congenitalsensorineuraldeafnessinaustralianstumpytailcattledogsisanautosomalrecessivetraitthatmapstocfa10
AT carolineaoleary congenitalsensorineuraldeafnessinaustralianstumpytailcattledogsisanautosomalrecessivetraitthatmapstocfa10
_version_ 1718423981697007616