Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study

Jordi Gatell-TortajadaOn behalf of the Large Dry Eye Clinical Study Group (LDECSG)Cornea and Ocular Surface Department, Institut Català de Retina, Barcelona, SpainPurpose: To assess the benefits and tolerability of a dietary supplement based on omega-3 fatty acids to relieve dry eye sympt...

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Autor principal:	Gatell-Tortajada J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	dry eye symptoms artificial tears omega-3 polyunsaturated fatty acids nutraceutical supplement ocular inflammation eye discomfort oxidative stress. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/692b039cb4b04e7da5f5ea373da6e2ee
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spelling	oai:doaj.org-article:692b039cb4b04e7da5f5ea373da6e2ee2021-12-02T04:10:36ZOral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study1178-1998https://doaj.org/article/692b039cb4b04e7da5f5ea373da6e2ee2016-05-01T00:00:00Zhttps://www.dovepress.com/oral-supplementation-with-a-nutraceutical-formulation-containing-omega-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jordi Gatell-TortajadaOn behalf of the Large Dry Eye Clinical Study Group (LDECSG)Cornea and Ocular Surface Department, Institut Català de Retina, Barcelona, SpainPurpose: To assess the benefits and tolerability of a dietary supplement based on omega-3 fatty acids to relieve dry eye symptoms.Methods: A total of 1,419 patients (74.3% women, mean age 58.9 years) with dry eye syndrome using artificial tears participated in a 12-week prospective study. Patients were instructed to take 3 capsules/day of the nutraceutical formulation (Brudysec® 1.5 g). Study variables were dry eye symptoms (scratchy and stinging sensation, eye redness, grittiness, painful and tired eyes, grating sensation, and blurry vision), conjunctival hyperemia, tear breakup time (TBUT), Schrimer I test, and Oxford grading scheme.Results: At 12 weeks, each dry eye symptom improved significantly (P<0.001), and the use of artificial tears decreased significantly from 3.77 (standard deviation [SD] =2.08) at baseline to 3.45 (SD =1.72) (P<0.01). In addition, the Schirmer test scores and the TBUT increased significantly, and there was an increase in patients grading 0–I in the Oxford scale and a decrease of those grading IV–V. Significant differences in improvements of dry eye symptoms were also found in compliant versus noncompliant patients as well as in those with moderate/severe versus none/mild conjunctival hyperemia.Conclusion: Oral ω-3 fatty acids supplementation was an effective treatment for dry eye symptoms.Keywords: dry eye symptoms, artificial tears, omega-3 polyunsaturated fatty acids, nutraceutical supplement, ocular inflammation, eye discomfortGatell-Tortajada JDove Medical Pressarticledry eye symptomsartificial tearsomega-3 polyunsaturated fatty acidsnutraceutical supplementocular inflammationeye discomfortoxidative stress.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 571-578 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye symptoms artificial tears omega-3 polyunsaturated fatty acids nutraceutical supplement ocular inflammation eye discomfort oxidative stress. Geriatrics RC952-954.6
spellingShingle	dry eye symptoms artificial tears omega-3 polyunsaturated fatty acids nutraceutical supplement ocular inflammation eye discomfort oxidative stress. Geriatrics RC952-954.6 Gatell-Tortajada J Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study
description	Jordi Gatell-TortajadaOn behalf of the Large Dry Eye Clinical Study Group (LDECSG)Cornea and Ocular Surface Department, Institut Català de Retina, Barcelona, SpainPurpose: To assess the benefits and tolerability of a dietary supplement based on omega-3 fatty acids to relieve dry eye symptoms.Methods: A total of 1,419 patients (74.3% women, mean age 58.9 years) with dry eye syndrome using artificial tears participated in a 12-week prospective study. Patients were instructed to take 3 capsules/day of the nutraceutical formulation (Brudysec® 1.5 g). Study variables were dry eye symptoms (scratchy and stinging sensation, eye redness, grittiness, painful and tired eyes, grating sensation, and blurry vision), conjunctival hyperemia, tear breakup time (TBUT), Schrimer I test, and Oxford grading scheme.Results: At 12 weeks, each dry eye symptom improved significantly (P<0.001), and the use of artificial tears decreased significantly from 3.77 (standard deviation [SD] =2.08) at baseline to 3.45 (SD =1.72) (P<0.01). In addition, the Schirmer test scores and the TBUT increased significantly, and there was an increase in patients grading 0–I in the Oxford scale and a decrease of those grading IV–V. Significant differences in improvements of dry eye symptoms were also found in compliant versus noncompliant patients as well as in those with moderate/severe versus none/mild conjunctival hyperemia.Conclusion: Oral ω-3 fatty acids supplementation was an effective treatment for dry eye symptoms.Keywords: dry eye symptoms, artificial tears, omega-3 polyunsaturated fatty acids, nutraceutical supplement, ocular inflammation, eye discomfort
format	article
author	Gatell-Tortajada J
author_facet	Gatell-Tortajada J
author_sort	Gatell-Tortajada J
title	Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study
title_short	Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study
title_full	Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study
title_fullStr	Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study
title_full_unstemmed	Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study
title_sort	oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/692b039cb4b04e7da5f5ea373da6e2ee
work_keys_str_mv	AT gatelltortajadaj oralsupplementationwithanutraceuticalformulationcontainingomega3fattyacidsvitaminsmineralsandantioxidantsinalargeseriesofpatientswithdryeyesymptomsresultsofaprospectivestudy
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Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study

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