The neurorepellent, Slit2, prevents macrophage lipid loading by inhibiting CD36-dependent binding and internalization of oxidized low-density lipoprotein

The neurorepellent, Slit2, prevents macrophage lipid loading by inhibiting CD36-dependent binding and internalization of oxidized low-density lipoprotein

Abstract Atherosclerosis is characterized by retention of modified lipoproteins, especially oxidized low density lipoprotein (oxLDL) within the sub-endothelial space of affected blood vessels. Recruited monocyte-derived and tissue-resident macrophages subsequently ingest oxLDL by binding and interna...

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Autores principales: Bushra Yusuf, Ilya Mukovozov, Sajedabanu Patel, Yi-Wei Huang, Guang Ying Liu, Emily C. Reddy, Marko Skrtic, Michael Glogauer, Lisa A. Robinson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/692c0813c2d5464cb7a9503427c02397
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