The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions

Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses. But autophagy—especially Atg proteins including Atg8 family members—can also hav...

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Autores principales:	Dávid Tóth, Gábor V. Horváth, Gábor Juhász
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	GABARAP hfAIM iLIR LC3 LIR motif SARS‐CoV‐2 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/692c78d47e8a4efc8ff00586accce125
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spelling	oai:doaj.org-article:692c78d47e8a4efc8ff00586accce1252021-12-01T13:36:12ZThe interplay between pathogens and Atg8 family proteins: thousand‐faced interactions2211-546310.1002/2211-5463.13318https://doaj.org/article/692c78d47e8a4efc8ff00586accce1252021-12-01T00:00:00Zhttps://doi.org/10.1002/2211-5463.13318https://doaj.org/toc/2211-5463Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses. But autophagy—especially Atg proteins including Atg8 family members—can also have proviral and probacterial effects. In this review, we summarize known interactions of bacterial, parasitic, and viral proteins with Atg8 family proteins and the outcome of these interactions on pathogen replication, autophagy, or mitophagy. We discuss the value of prediction software and the research methodology in the study of pathogen protein‐Atg8 family protein interactions, with selected examples of potential LC3‐interacting region motif‐containing SARS‐CoV‐2 proteins.Dávid TóthGábor V. HorváthGábor JuhászWileyarticleGABARAPhfAIMiLIRLC3LIR motifSARS‐CoV‐2Biology (General)QH301-705.5ENFEBS Open Bio, Vol 11, Iss 12, Pp 3237-3252 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GABARAP hfAIM iLIR LC3 LIR motif SARS‐CoV‐2 Biology (General) QH301-705.5
spellingShingle	GABARAP hfAIM iLIR LC3 LIR motif SARS‐CoV‐2 Biology (General) QH301-705.5 Dávid Tóth Gábor V. Horváth Gábor Juhász The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions
description	Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses. But autophagy—especially Atg proteins including Atg8 family members—can also have proviral and probacterial effects. In this review, we summarize known interactions of bacterial, parasitic, and viral proteins with Atg8 family proteins and the outcome of these interactions on pathogen replication, autophagy, or mitophagy. We discuss the value of prediction software and the research methodology in the study of pathogen protein‐Atg8 family protein interactions, with selected examples of potential LC3‐interacting region motif‐containing SARS‐CoV‐2 proteins.
format	article
author	Dávid Tóth Gábor V. Horváth Gábor Juhász
author_facet	Dávid Tóth Gábor V. Horváth Gábor Juhász
author_sort	Dávid Tóth
title	The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions
title_short	The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions
title_full	The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions
title_fullStr	The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions
title_full_unstemmed	The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions
title_sort	interplay between pathogens and atg8 family proteins: thousand‐faced interactions
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/692c78d47e8a4efc8ff00586accce125
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The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions

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