Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study

Seongmoon Jung,1,2 Wonmo Sung,1,2 Sung-Joon Ye1–3 1Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; 2Biomedical Research Institute, College of Medicine, Seoul National University, Seoul, Re...

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Autores principales:	Jung S, Sung W, Ye SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	X-ray fluorescence pinhole nanoparticles bio-imaging CNR radiation dose Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/693427a948a0456c83572a2009bcbe31
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spelling	oai:doaj.org-article:693427a948a0456c83572a2009bcbe312021-12-02T02:41:15ZPinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study1178-2013https://doaj.org/article/693427a948a0456c83572a2009bcbe312017-08-01T00:00:00Zhttps://www.dovepress.com/pinhole-x-ray-fluorescence-imaging-of-gadolinium-and-gold-nanoparticle-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Seongmoon Jung,1,2 Wonmo Sung,1,2 Sung-Joon Ye1–3 1Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; 2Biomedical Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea; 3Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea Abstract: This work aims to develop a Monte Carlo (MC) model for pinhole K-shell X-ray fluorescence (XRF) imaging of metal nanoparticles using polychromatic X-rays. The MC model consisted of two-dimensional (2D) position-sensitive detectors and fan-beam X-rays used to stimulate the emission of XRF photons from gadolinium (Gd) or gold (Au) nanoparticles. Four cylindrical columns containing different concentrations of nanoparticles ranging from 0.01% to 0.09% by weight (wt%) were placed in a 5 cm diameter cylindrical water phantom. The images of the columns had detectable contrast-to-noise ratios (CNRs) of 5.7 and 4.3 for 0.01 wt% Gd and for 0.03 wt% Au, respectively. Higher concentrations of nanoparticles yielded higher CNR. For 1×1011 incident particles, the radiation dose to the phantom was 19.9 mGy for 110 kVp X-rays (Gd imaging) and 26.1 mGy for 140 kVp X-rays (Au imaging). The MC model of a pinhole XRF can acquire direct 2D slice images of the object without image reconstruction. The MC model demonstrated that the pinhole XRF imaging system could be a potential bioimaging modality for nanomedicine. Keywords: X-ray fluorescence, pinhole, nanoparticles, bioimaging, CNR, radiation dose Jung SSung WYe SJDove Medical PressarticleX-ray fluorescencepinholenanoparticlesbio-imagingCNRradiation doseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5805-5817 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	X-ray fluorescence pinhole nanoparticles bio-imaging CNR radiation dose Medicine (General) R5-920
spellingShingle	X-ray fluorescence pinhole nanoparticles bio-imaging CNR radiation dose Medicine (General) R5-920 Jung S Sung W Ye SJ Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study
description	Seongmoon Jung,1,2 Wonmo Sung,1,2 Sung-Joon Ye1–3 1Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; 2Biomedical Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea; 3Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea Abstract: This work aims to develop a Monte Carlo (MC) model for pinhole K-shell X-ray fluorescence (XRF) imaging of metal nanoparticles using polychromatic X-rays. The MC model consisted of two-dimensional (2D) position-sensitive detectors and fan-beam X-rays used to stimulate the emission of XRF photons from gadolinium (Gd) or gold (Au) nanoparticles. Four cylindrical columns containing different concentrations of nanoparticles ranging from 0.01% to 0.09% by weight (wt%) were placed in a 5 cm diameter cylindrical water phantom. The images of the columns had detectable contrast-to-noise ratios (CNRs) of 5.7 and 4.3 for 0.01 wt% Gd and for 0.03 wt% Au, respectively. Higher concentrations of nanoparticles yielded higher CNR. For 1×1011 incident particles, the radiation dose to the phantom was 19.9 mGy for 110 kVp X-rays (Gd imaging) and 26.1 mGy for 140 kVp X-rays (Au imaging). The MC model of a pinhole XRF can acquire direct 2D slice images of the object without image reconstruction. The MC model demonstrated that the pinhole XRF imaging system could be a potential bioimaging modality for nanomedicine. Keywords: X-ray fluorescence, pinhole, nanoparticles, bioimaging, CNR, radiation dose
format	article
author	Jung S Sung W Ye SJ
author_facet	Jung S Sung W Ye SJ
author_sort	Jung S
title	Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study
title_short	Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study
title_full	Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study
title_fullStr	Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study
title_full_unstemmed	Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study
title_sort	pinhole x-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic x-rays: a monte carlo study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/693427a948a0456c83572a2009bcbe31
work_keys_str_mv	AT jungs pinholexrayfluorescenceimagingofgadoliniumandgoldnanoparticlesusingpolychromaticxraysamontecarlostudy AT sungw pinholexrayfluorescenceimagingofgadoliniumandgoldnanoparticlesusingpolychromaticxraysamontecarlostudy AT yesj pinholexrayfluorescenceimagingofgadoliniumandgoldnanoparticlesusingpolychromaticxraysamontecarlostudy
_version_	1718402291658129408

Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays: a Monte Carlo study

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