Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus

Abstract Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation. Globally, the prevalence of T2D has increased dramatically in...

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Autores principales:	Zhi Yang Tam, Sean Pin Ng, Ling Qiao Tan, Chih-Hsien Lin, Dietrich Rothenbacher, Jochen Klenk, Bernhard Otto Boehm, SPC Team, ActiFE Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69343e65f84a4c9a91fbf0951728d1b4
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spelling	oai:doaj.org-article:69343e65f84a4c9a91fbf0951728d1b42021-12-02T16:06:05ZMetabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus10.1038/s41598-017-01735-y2045-2322https://doaj.org/article/69343e65f84a4c9a91fbf0951728d1b42017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01735-yhttps://doaj.org/toc/2045-2322Abstract Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation. Globally, the prevalence of T2D has increased dramatically in all age groups. T2D in older adults is associated with higher mortality and reduced functional status, leading to higher rate of institutionalization. Despite the potential healthcare challenges associated with the presence of T2D in the elderly, the pathogenesis and phenotype of late-onset T2D is not well studied. Here we applied untargeted metabolite profiling of urine samples from people with and without late-onset T2D using ultra-performance liquid-chromatography mass-spectrometry (UPLC-MS) to identify urinary biomarkers for late-onset T2D in the elderly. Statistical modeling of measurements and thorough validation of structural assignment using liquid chromatography tandem mass-spectrometry (LC-MS/MS) have led to the identification of metabolite biomarkers associated with late-onset T2D. Lower levels of phenylalanine, acetylhistidine, and cyclic adenosine monophosphate (cAMP) were found in urine samples of T2D subjects validated with commercial standards. Elevated levels of 5′-methylthioadenosine (MTA), which previously has only been implicated in animal model of diabetes, was found in urine of older people with T2D.Zhi Yang TamSean Pin NgLing Qiao TanChih-Hsien LinDietrich RothenbacherJochen KlenkBernhard Otto BoehmSPC TeamActiFE Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhi Yang Tam Sean Pin Ng Ling Qiao Tan Chih-Hsien Lin Dietrich Rothenbacher Jochen Klenk Bernhard Otto Boehm SPC Team ActiFE Study Group Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
description	Abstract Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation. Globally, the prevalence of T2D has increased dramatically in all age groups. T2D in older adults is associated with higher mortality and reduced functional status, leading to higher rate of institutionalization. Despite the potential healthcare challenges associated with the presence of T2D in the elderly, the pathogenesis and phenotype of late-onset T2D is not well studied. Here we applied untargeted metabolite profiling of urine samples from people with and without late-onset T2D using ultra-performance liquid-chromatography mass-spectrometry (UPLC-MS) to identify urinary biomarkers for late-onset T2D in the elderly. Statistical modeling of measurements and thorough validation of structural assignment using liquid chromatography tandem mass-spectrometry (LC-MS/MS) have led to the identification of metabolite biomarkers associated with late-onset T2D. Lower levels of phenylalanine, acetylhistidine, and cyclic adenosine monophosphate (cAMP) were found in urine samples of T2D subjects validated with commercial standards. Elevated levels of 5′-methylthioadenosine (MTA), which previously has only been implicated in animal model of diabetes, was found in urine of older people with T2D.
format	article
author	Zhi Yang Tam Sean Pin Ng Ling Qiao Tan Chih-Hsien Lin Dietrich Rothenbacher Jochen Klenk Bernhard Otto Boehm SPC Team ActiFE Study Group
author_facet	Zhi Yang Tam Sean Pin Ng Ling Qiao Tan Chih-Hsien Lin Dietrich Rothenbacher Jochen Klenk Bernhard Otto Boehm SPC Team ActiFE Study Group
author_sort	Zhi Yang Tam
title	Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
title_short	Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
title_full	Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
title_fullStr	Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
title_full_unstemmed	Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
title_sort	metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/69343e65f84a4c9a91fbf0951728d1b4
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Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus

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