Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.

Our limited ability to assess spontaneous pain in rodent models of painful human conditions may be associated with a translational failure of promising analgesic compounds in to clinical use. If measurement of spontaneous pain behaviours can be used to generate an analgesic intervention score their...

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Autores principales:	Vanessa Oliver, Debbie De Rantere, Rheanne Ritchie, Jessica Chisholm, Kent G Hecker, Daniel S J Pang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6934e37920364b1ca7533948b51cf277
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spelling	oai:doaj.org-article:6934e37920364b1ca7533948b51cf2772021-11-18T08:18:52ZPsychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.1932-620310.1371/journal.pone.0097882https://doaj.org/article/6934e37920364b1ca7533948b51cf2772014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24838111/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Our limited ability to assess spontaneous pain in rodent models of painful human conditions may be associated with a translational failure of promising analgesic compounds in to clinical use. If measurement of spontaneous pain behaviours can be used to generate an analgesic intervention score their use could expand to guide the use of analgesics, as mandated by regulatory bodies and ethical and welfare obligations. One such measure of spontaneous pain, the Rat Grimace Scale (RGS), has recently been described and shown to exhibit reliability. However, reliability of measurement scores is context and content specific, and further testing required to assess translation to a heterogenous setting (different model, raters, environment). The objectives of this study were to perform reliability testing with the Rat Grimace Scale in a heterogenous setting and generate an analgesic intervention score for its use. In a randomised, blinded study, sixteen adult female rats received one of three analgesia treatments (0.05 mg/kg buprenorphine subcutaneously, 1 mg/kg meloxicam subcutaneously, 0.2 mg/kg oral buprenorphine in jelly) peri-operatively (telemetry unit implantation surgery). Rats were video-recorded (before, 1-6 and 12 hours post-operatively) and images collected for independent scoring by three blinded raters using the RGS, and five experts based on "pain/no pain" assessment. Scores were used to calculate inter- and intra-rater reliability with an intraclass correlation coefficient and generate an analgesic intervention score with receiver operating characteristic curve analysis. The RGS scores showed very good inter- and intra-rater reliability (0.85 [0.78-0.90 95% CI] and 0.83 [0.76-0.89], respectively). An analgesic intervention threshold of greater than 0.67 was determined. These data demonstrate that the RGS is a useful tool which can be successfully employed in a heterogenous setting, and has the potential to guide analgesic intervention.Vanessa OliverDebbie De RantereRheanne RitchieJessica ChisholmKent G HeckerDaniel S J PangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97882 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanessa Oliver Debbie De Rantere Rheanne Ritchie Jessica Chisholm Kent G Hecker Daniel S J Pang Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.
description	Our limited ability to assess spontaneous pain in rodent models of painful human conditions may be associated with a translational failure of promising analgesic compounds in to clinical use. If measurement of spontaneous pain behaviours can be used to generate an analgesic intervention score their use could expand to guide the use of analgesics, as mandated by regulatory bodies and ethical and welfare obligations. One such measure of spontaneous pain, the Rat Grimace Scale (RGS), has recently been described and shown to exhibit reliability. However, reliability of measurement scores is context and content specific, and further testing required to assess translation to a heterogenous setting (different model, raters, environment). The objectives of this study were to perform reliability testing with the Rat Grimace Scale in a heterogenous setting and generate an analgesic intervention score for its use. In a randomised, blinded study, sixteen adult female rats received one of three analgesia treatments (0.05 mg/kg buprenorphine subcutaneously, 1 mg/kg meloxicam subcutaneously, 0.2 mg/kg oral buprenorphine in jelly) peri-operatively (telemetry unit implantation surgery). Rats were video-recorded (before, 1-6 and 12 hours post-operatively) and images collected for independent scoring by three blinded raters using the RGS, and five experts based on "pain/no pain" assessment. Scores were used to calculate inter- and intra-rater reliability with an intraclass correlation coefficient and generate an analgesic intervention score with receiver operating characteristic curve analysis. The RGS scores showed very good inter- and intra-rater reliability (0.85 [0.78-0.90 95% CI] and 0.83 [0.76-0.89], respectively). An analgesic intervention threshold of greater than 0.67 was determined. These data demonstrate that the RGS is a useful tool which can be successfully employed in a heterogenous setting, and has the potential to guide analgesic intervention.
format	article
author	Vanessa Oliver Debbie De Rantere Rheanne Ritchie Jessica Chisholm Kent G Hecker Daniel S J Pang
author_facet	Vanessa Oliver Debbie De Rantere Rheanne Ritchie Jessica Chisholm Kent G Hecker Daniel S J Pang
author_sort	Vanessa Oliver
title	Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.
title_short	Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.
title_full	Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.
title_fullStr	Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.
title_full_unstemmed	Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.
title_sort	psychometric assessment of the rat grimace scale and development of an analgesic intervention score.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6934e37920364b1ca7533948b51cf277
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Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score.

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