Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.

<h4>Objectives</h4>Treatment of diabetic subjects with cinnamon demonstrated an improvement in blood glucose concentrations and insulin sensitivity but the underlying mechanisms remained unclear. This work intends to elucidate the impact of cinnamon effects on the brain by using isolated...

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Autores principales:	Tina Sartorius, Andreas Peter, Nadja Schulz, Andrea Drescher, Ina Bergheim, Jürgen Machann, Fritz Schick, Dorothea Siegel-Axel, Annette Schürmann, Cora Weigert, Hans-Ulrich Häring, Anita M Hennige
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6935645501204ac9b63292f29c3d4fcc
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spelling	oai:doaj.org-article:6935645501204ac9b63292f29c3d4fcc2021-11-18T08:27:31ZCinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.1932-620310.1371/journal.pone.0092358https://doaj.org/article/6935645501204ac9b63292f29c3d4fcc2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24643026/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Treatment of diabetic subjects with cinnamon demonstrated an improvement in blood glucose concentrations and insulin sensitivity but the underlying mechanisms remained unclear. This work intends to elucidate the impact of cinnamon effects on the brain by using isolated astrocytes, and an obese and diabetic mouse model.<h4>Methods</h4>Cinnamon components (eugenol, cinnamaldehyde) were added to astrocytes and liver cells to measure insulin signaling and glycogen synthesis. Ob/ob mice were supplemented with extract from cinnamomum zeylanicum for 6 weeks and cortical brain activity, locomotion and energy expenditure were evaluated. Insulin action was determined in brain and liver tissues.<h4>Results</h4>Treatment of primary astrocytes with eugenol promoted glycogen synthesis, whereas the effect of cinnamaldehyde was attenuated. In terms of brain function in vivo, cinnamon extract improved insulin sensitivity and brain activity in ob/ob mice, and the insulin-stimulated locomotor activity was improved. In addition, fasting blood glucose levels and glucose tolerance were greatly improved in ob/ob mice due to cinnamon extracts, while insulin secretion was unaltered. This corresponded with lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues. In vitro, Fao cells exposed to cinnamon exhibited no change in insulin action.<h4>Conclusions</h4>Together, cinnamon extract improved insulin action in the brain as well as brain activity and locomotion. This specific effect may represent an important central feature of cinnamon in improving insulin action in the brain, and mediates metabolic alterations in the periphery to decrease liver fat and improve glucose homeostasis.Tina SartoriusAndreas PeterNadja SchulzAndrea DrescherIna BergheimJürgen MachannFritz SchickDorothea Siegel-AxelAnnette SchürmannCora WeigertHans-Ulrich HäringAnita M HennigePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e92358 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tina Sartorius Andreas Peter Nadja Schulz Andrea Drescher Ina Bergheim Jürgen Machann Fritz Schick Dorothea Siegel-Axel Annette Schürmann Cora Weigert Hans-Ulrich Häring Anita M Hennige Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
description	<h4>Objectives</h4>Treatment of diabetic subjects with cinnamon demonstrated an improvement in blood glucose concentrations and insulin sensitivity but the underlying mechanisms remained unclear. This work intends to elucidate the impact of cinnamon effects on the brain by using isolated astrocytes, and an obese and diabetic mouse model.<h4>Methods</h4>Cinnamon components (eugenol, cinnamaldehyde) were added to astrocytes and liver cells to measure insulin signaling and glycogen synthesis. Ob/ob mice were supplemented with extract from cinnamomum zeylanicum for 6 weeks and cortical brain activity, locomotion and energy expenditure were evaluated. Insulin action was determined in brain and liver tissues.<h4>Results</h4>Treatment of primary astrocytes with eugenol promoted glycogen synthesis, whereas the effect of cinnamaldehyde was attenuated. In terms of brain function in vivo, cinnamon extract improved insulin sensitivity and brain activity in ob/ob mice, and the insulin-stimulated locomotor activity was improved. In addition, fasting blood glucose levels and glucose tolerance were greatly improved in ob/ob mice due to cinnamon extracts, while insulin secretion was unaltered. This corresponded with lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues. In vitro, Fao cells exposed to cinnamon exhibited no change in insulin action.<h4>Conclusions</h4>Together, cinnamon extract improved insulin action in the brain as well as brain activity and locomotion. This specific effect may represent an important central feature of cinnamon in improving insulin action in the brain, and mediates metabolic alterations in the periphery to decrease liver fat and improve glucose homeostasis.
format	article
author	Tina Sartorius Andreas Peter Nadja Schulz Andrea Drescher Ina Bergheim Jürgen Machann Fritz Schick Dorothea Siegel-Axel Annette Schürmann Cora Weigert Hans-Ulrich Häring Anita M Hennige
author_facet	Tina Sartorius Andreas Peter Nadja Schulz Andrea Drescher Ina Bergheim Jürgen Machann Fritz Schick Dorothea Siegel-Axel Annette Schürmann Cora Weigert Hans-Ulrich Häring Anita M Hennige
author_sort	Tina Sartorius
title	Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
title_short	Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
title_full	Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
title_fullStr	Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
title_full_unstemmed	Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
title_sort	cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6935645501204ac9b63292f29c3d4fcc
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Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.

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