Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations

Patients with diabetes are over-represented among the total cases reported with “idiopathic” pulmonary fibrosis (IPF). This raises the question, whether this is an association only or whether diabetes itself can cause pulmonary fibrosis. Recent studies in mouse models of type 1 and type 2 diabetes d...

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Autores principales:	Stefan Kopf, Varun Kumar, Zoltan Kender, Zhe Han, Thomas Fleming, Stephan Herzig, Peter P. Nawroth
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diabetes pulmonary fibrosis senescence persistent DNA damage signaling hyperglycemia Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/6935a40a767148a7979d9c2305fae865
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spelling	oai:doaj.org-article:6935a40a767148a7979d9c2305fae8652021-11-30T23:22:44ZDiabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations1664-239210.3389/fendo.2021.765201https://doaj.org/article/6935a40a767148a7979d9c2305fae8652021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.765201/fullhttps://doaj.org/toc/1664-2392Patients with diabetes are over-represented among the total cases reported with “idiopathic” pulmonary fibrosis (IPF). This raises the question, whether this is an association only or whether diabetes itself can cause pulmonary fibrosis. Recent studies in mouse models of type 1 and type 2 diabetes demonstrated that diabetes causes pulmonary fibrosis. Both types of diabetes trigger a cascade, starting with increased DNA damage, an impaired DNA repair, and leading to persistent DNA damage signaling. This response, in turn, induces senescence, a senescence-associated-secretory phenotype (SASP), marked by the release of pro-inflammatory cytokines and growth factors, finally resulting in fibrosis. Restoring DNA repair drives fibrosis into remission, thus proving causality. These data can be translated clinically to patients with type 2 diabetes, characterized by long-term diabetes and albuminuria. Hence there are several arguments, to substitute the term “idiopathic” pulmonary fibrosis (IPF) in patients with diabetes (and exclusion of other causes of lung diseases) by the term “diabetes-induced pulmonary fibrosis” (DiPF). However, future studies are required to establish this term and to study whether patients with diabetes respond to the established therapies similar to non-diabetic patients.Stefan KopfStefan KopfVarun KumarVarun KumarVarun KumarZoltan KenderZoltan KenderZhe HanThomas FlemingThomas FlemingStephan HerzigStephan HerzigStephan HerzigPeter P. NawrothPeter P. NawrothPeter P. NawrothFrontiers Media S.A.articlediabetespulmonary fibrosissenescencepersistent DNA damage signalinghyperglycemiaDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes pulmonary fibrosis senescence persistent DNA damage signaling hyperglycemia Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	diabetes pulmonary fibrosis senescence persistent DNA damage signaling hyperglycemia Diseases of the endocrine glands. Clinical endocrinology RC648-665 Stefan Kopf Stefan Kopf Varun Kumar Varun Kumar Varun Kumar Zoltan Kender Zoltan Kender Zhe Han Thomas Fleming Thomas Fleming Stephan Herzig Stephan Herzig Stephan Herzig Peter P. Nawroth Peter P. Nawroth Peter P. Nawroth Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
description	Patients with diabetes are over-represented among the total cases reported with “idiopathic” pulmonary fibrosis (IPF). This raises the question, whether this is an association only or whether diabetes itself can cause pulmonary fibrosis. Recent studies in mouse models of type 1 and type 2 diabetes demonstrated that diabetes causes pulmonary fibrosis. Both types of diabetes trigger a cascade, starting with increased DNA damage, an impaired DNA repair, and leading to persistent DNA damage signaling. This response, in turn, induces senescence, a senescence-associated-secretory phenotype (SASP), marked by the release of pro-inflammatory cytokines and growth factors, finally resulting in fibrosis. Restoring DNA repair drives fibrosis into remission, thus proving causality. These data can be translated clinically to patients with type 2 diabetes, characterized by long-term diabetes and albuminuria. Hence there are several arguments, to substitute the term “idiopathic” pulmonary fibrosis (IPF) in patients with diabetes (and exclusion of other causes of lung diseases) by the term “diabetes-induced pulmonary fibrosis” (DiPF). However, future studies are required to establish this term and to study whether patients with diabetes respond to the established therapies similar to non-diabetic patients.
format	article
author	Stefan Kopf Stefan Kopf Varun Kumar Varun Kumar Varun Kumar Zoltan Kender Zoltan Kender Zhe Han Thomas Fleming Thomas Fleming Stephan Herzig Stephan Herzig Stephan Herzig Peter P. Nawroth Peter P. Nawroth Peter P. Nawroth
author_facet	Stefan Kopf Stefan Kopf Varun Kumar Varun Kumar Varun Kumar Zoltan Kender Zoltan Kender Zhe Han Thomas Fleming Thomas Fleming Stephan Herzig Stephan Herzig Stephan Herzig Peter P. Nawroth Peter P. Nawroth Peter P. Nawroth
author_sort	Stefan Kopf
title	Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
title_short	Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
title_full	Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
title_fullStr	Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
title_full_unstemmed	Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
title_sort	diabetic pneumopathy–a new diabetes-associated complication: mechanisms, consequences and treatment considerations
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6935a40a767148a7979d9c2305fae865
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Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations

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