Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep

Abstract Subjective–objective discrepancy of sleep (SODS) might be related to the distorted perception of sleep deficit and hypersensitivity to insomnia-related stimuli. We investigated differences in brain activation to insomnia-related stimuli among insomnia patients with SODS (SODS group), insomn...

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Autores principales:	Young-Bo Kim, Nambeom Kim, Jae Jun Lee, Seo-Eun Cho, Kyoung-Sae Na, Seung-Gul Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6936876b827c4529bf98cf0ffdc8e288
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spelling	oai:doaj.org-article:6936876b827c4529bf98cf0ffdc8e2882021-12-02T15:22:58ZBrain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep10.1038/s41598-021-81219-22045-2322https://doaj.org/article/6936876b827c4529bf98cf0ffdc8e2882021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81219-2https://doaj.org/toc/2045-2322Abstract Subjective–objective discrepancy of sleep (SODS) might be related to the distorted perception of sleep deficit and hypersensitivity to insomnia-related stimuli. We investigated differences in brain activation to insomnia-related stimuli among insomnia patients with SODS (SODS group), insomnia patients without SODS (NOSODS group), and healthy controls (HC). Participants were evaluated for subjective and objective sleep using sleep diary and polysomnography. Functional magnetic resonance imaging was conducted during the presentation of insomnia-related (Ins), general anxiety-inducing (Gen), and neutral (Neu) stimuli. Brain reactivity to the contrast of Ins vs. Neu and Gen vs. Neu was compared among the SODS (n = 13), NOSODS (n = 15), and HC (n = 16) groups. In the SODS group compared to other groups, brain areas including the left fusiform, bilateral precuneus, right superior frontal gyrus, genu of corpus callosum, and bilateral anterior corona radiata showed significantly increased blood oxygen level dependent (BOLD) signal in the contrast of Ins vs. Neu. There was no brain region with significantly increased BOLD signal in the Gen vs. Neu contrast in the group comparisons. Increased brain activity to insomnia-related stimuli in several brain regions of the SODS group is likely due to these individuals being more sensitive to sleep-related threat and negative cognitive distortion toward insomnia.Young-Bo KimNambeom KimJae Jun LeeSeo-Eun ChoKyoung-Sae NaSeung-Gul KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young-Bo Kim Nambeom Kim Jae Jun Lee Seo-Eun Cho Kyoung-Sae Na Seung-Gul Kang Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep
description	Abstract Subjective–objective discrepancy of sleep (SODS) might be related to the distorted perception of sleep deficit and hypersensitivity to insomnia-related stimuli. We investigated differences in brain activation to insomnia-related stimuli among insomnia patients with SODS (SODS group), insomnia patients without SODS (NOSODS group), and healthy controls (HC). Participants were evaluated for subjective and objective sleep using sleep diary and polysomnography. Functional magnetic resonance imaging was conducted during the presentation of insomnia-related (Ins), general anxiety-inducing (Gen), and neutral (Neu) stimuli. Brain reactivity to the contrast of Ins vs. Neu and Gen vs. Neu was compared among the SODS (n = 13), NOSODS (n = 15), and HC (n = 16) groups. In the SODS group compared to other groups, brain areas including the left fusiform, bilateral precuneus, right superior frontal gyrus, genu of corpus callosum, and bilateral anterior corona radiata showed significantly increased blood oxygen level dependent (BOLD) signal in the contrast of Ins vs. Neu. There was no brain region with significantly increased BOLD signal in the Gen vs. Neu contrast in the group comparisons. Increased brain activity to insomnia-related stimuli in several brain regions of the SODS group is likely due to these individuals being more sensitive to sleep-related threat and negative cognitive distortion toward insomnia.
format	article
author	Young-Bo Kim Nambeom Kim Jae Jun Lee Seo-Eun Cho Kyoung-Sae Na Seung-Gul Kang
author_facet	Young-Bo Kim Nambeom Kim Jae Jun Lee Seo-Eun Cho Kyoung-Sae Na Seung-Gul Kang
author_sort	Young-Bo Kim
title	Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep
title_short	Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep
title_full	Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep
title_fullStr	Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep
title_full_unstemmed	Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep
title_sort	brain reactivity using fmri to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6936876b827c4529bf98cf0ffdc8e288
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Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep

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