HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis
Osteoporosis is a prevalent bone disorder characterized by bone mass reduction and deterioration of bone microarchitecture leading to bone fragility and fracture risk. In recent decades, knowledge regarding the etiological mechanisms emphasizes that inflammation, oxidative stress and senescence of b...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:693aac44eae04d21845e7a65108eeb2d2021-12-01T18:51:32ZHO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis2296-634X10.3389/fcell.2021.791585https://doaj.org/article/693aac44eae04d21845e7a65108eeb2d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.791585/fullhttps://doaj.org/toc/2296-634XOsteoporosis is a prevalent bone disorder characterized by bone mass reduction and deterioration of bone microarchitecture leading to bone fragility and fracture risk. In recent decades, knowledge regarding the etiological mechanisms emphasizes that inflammation, oxidative stress and senescence of bone cells contribute to the development of osteoporosis. Studies have demonstrated that heme oxygenase 1 (HO-1), an inducible enzyme catalyzing heme degradation, exhibits anti-inflammatory, anti-oxidative stress and anti-apoptosis properties. Emerging evidence has revealed that HO-1 is critical in the maintenance of bone homeostasis, making HO-1 a potential target for osteoporosis treatment. In this Review, we aim to provide an introduction to current knowledge of HO-1 biology and its regulation, focusing specifically on its roles in bone homeostasis and osteoporosis. We also examine the potential of HO-1-based pharmacological therapeutics for osteoporosis and issues faced during clinical translation.Xueman ZhouXueman ZhouWenxiu YuanWenxiu YuanXin XiongZhenzhen ZhangZhenzhen ZhangJiaqi LiuJiaqi LiuYingcheng ZhengYingcheng ZhengJun WangJin LiuFrontiers Media S.A.articlebone remodelingosteoporosispharmacological therapeuticsHO-1 inducerheme oxygenase 1 (HO-1)Biology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
bone remodeling osteoporosis pharmacological therapeutics HO-1 inducer heme oxygenase 1 (HO-1) Biology (General) QH301-705.5 |
| spellingShingle |
bone remodeling osteoporosis pharmacological therapeutics HO-1 inducer heme oxygenase 1 (HO-1) Biology (General) QH301-705.5 Xueman Zhou Xueman Zhou Wenxiu Yuan Wenxiu Yuan Xin Xiong Zhenzhen Zhang Zhenzhen Zhang Jiaqi Liu Jiaqi Liu Yingcheng Zheng Yingcheng Zheng Jun Wang Jin Liu HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis |
| description |
Osteoporosis is a prevalent bone disorder characterized by bone mass reduction and deterioration of bone microarchitecture leading to bone fragility and fracture risk. In recent decades, knowledge regarding the etiological mechanisms emphasizes that inflammation, oxidative stress and senescence of bone cells contribute to the development of osteoporosis. Studies have demonstrated that heme oxygenase 1 (HO-1), an inducible enzyme catalyzing heme degradation, exhibits anti-inflammatory, anti-oxidative stress and anti-apoptosis properties. Emerging evidence has revealed that HO-1 is critical in the maintenance of bone homeostasis, making HO-1 a potential target for osteoporosis treatment. In this Review, we aim to provide an introduction to current knowledge of HO-1 biology and its regulation, focusing specifically on its roles in bone homeostasis and osteoporosis. We also examine the potential of HO-1-based pharmacological therapeutics for osteoporosis and issues faced during clinical translation. |
| format |
article |
| author |
Xueman Zhou Xueman Zhou Wenxiu Yuan Wenxiu Yuan Xin Xiong Zhenzhen Zhang Zhenzhen Zhang Jiaqi Liu Jiaqi Liu Yingcheng Zheng Yingcheng Zheng Jun Wang Jin Liu |
| author_facet |
Xueman Zhou Xueman Zhou Wenxiu Yuan Wenxiu Yuan Xin Xiong Zhenzhen Zhang Zhenzhen Zhang Jiaqi Liu Jiaqi Liu Yingcheng Zheng Yingcheng Zheng Jun Wang Jin Liu |
| author_sort |
Xueman Zhou |
| title |
HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis |
| title_short |
HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis |
| title_full |
HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis |
| title_fullStr |
HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis |
| title_full_unstemmed |
HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis |
| title_sort |
ho-1 in bone biology: potential therapeutic strategies for osteoporosis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/693aac44eae04d21845e7a65108eeb2d |
| work_keys_str_mv |
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