Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through...

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Autores principales:	Ming-Hsien Chan, Bo-Gu Chen, Loan Thi Ngo, Wen-Tse Huang, Chien-Hsiu Li, Ru-Shi Liu, Michael Hsiao
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	natural carbon nanodots tumor-targeting probes biosensing cancer theranostic toxicity assessment Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/693c377adc9f4153b8a879687573ad98
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spelling	oai:doaj.org-article:693c377adc9f4153b8a879687573ad982021-11-25T18:41:21ZNatural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application10.3390/pharmaceutics131118741999-4923https://doaj.org/article/693c377adc9f4153b8a879687573ad982021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1874https://doaj.org/toc/1999-4923This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through the production of reactive oxygen species (ROS), thereby causing cell auto-apoptosis. Recent research has found that CDs derived from organic carbon sources can treat cancer cells as effectively as conventional drugs without causing damage to normal cells. CDs obtained by heating a natural carbon source inherit properties similar to the carbon source from which they are derived. Importantly, these characteristics can be exploited to perform non-invasive targeted therapy on human cancers, avoiding the harm caused to the human body by conventional treatments. CDs are attractive for large-scale clinical applications. Water, herbs, plants, and probiotics are ideal carbon-containing sources that can be used to synthesize therapeutic and diagnostic CDs that have become the focus of attention due to their excellent light stability, fluorescence, good biocompatibility, and low toxicity. They can be applied as biosensors, bioimaging, diagnosis, and treatment applications. These advantages make CDs attractive for large-scale clinical application, providing new technologies and methods for disease occurrence, diagnosis, and treatment research.Ming-Hsien ChanBo-Gu ChenLoan Thi NgoWen-Tse HuangChien-Hsiu LiRu-Shi LiuMichael HsiaoMDPI AGarticlenatural carbon nanodotstumor-targeting probesbiosensingcancer theranostictoxicity assessmentPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1874, p 1874 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	natural carbon nanodots tumor-targeting probes biosensing cancer theranostic toxicity assessment Pharmacy and materia medica RS1-441
spellingShingle	natural carbon nanodots tumor-targeting probes biosensing cancer theranostic toxicity assessment Pharmacy and materia medica RS1-441 Ming-Hsien Chan Bo-Gu Chen Loan Thi Ngo Wen-Tse Huang Chien-Hsiu Li Ru-Shi Liu Michael Hsiao Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application
description	This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through the production of reactive oxygen species (ROS), thereby causing cell auto-apoptosis. Recent research has found that CDs derived from organic carbon sources can treat cancer cells as effectively as conventional drugs without causing damage to normal cells. CDs obtained by heating a natural carbon source inherit properties similar to the carbon source from which they are derived. Importantly, these characteristics can be exploited to perform non-invasive targeted therapy on human cancers, avoiding the harm caused to the human body by conventional treatments. CDs are attractive for large-scale clinical applications. Water, herbs, plants, and probiotics are ideal carbon-containing sources that can be used to synthesize therapeutic and diagnostic CDs that have become the focus of attention due to their excellent light stability, fluorescence, good biocompatibility, and low toxicity. They can be applied as biosensors, bioimaging, diagnosis, and treatment applications. These advantages make CDs attractive for large-scale clinical application, providing new technologies and methods for disease occurrence, diagnosis, and treatment research.
format	article
author	Ming-Hsien Chan Bo-Gu Chen Loan Thi Ngo Wen-Tse Huang Chien-Hsiu Li Ru-Shi Liu Michael Hsiao
author_facet	Ming-Hsien Chan Bo-Gu Chen Loan Thi Ngo Wen-Tse Huang Chien-Hsiu Li Ru-Shi Liu Michael Hsiao
author_sort	Ming-Hsien Chan
title	Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application
title_short	Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application
title_full	Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application
title_fullStr	Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application
title_full_unstemmed	Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application
title_sort	natural carbon nanodots: toxicity assessment and theranostic biological application
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/693c377adc9f4153b8a879687573ad98
work_keys_str_mv	AT minghsienchan naturalcarbonnanodotstoxicityassessmentandtheranosticbiologicalapplication AT boguchen naturalcarbonnanodotstoxicityassessmentandtheranosticbiologicalapplication AT loanthingo naturalcarbonnanodotstoxicityassessmentandtheranosticbiologicalapplication AT wentsehuang naturalcarbonnanodotstoxicityassessmentandtheranosticbiologicalapplication AT chienhsiuli naturalcarbonnanodotstoxicityassessmentandtheranosticbiologicalapplication AT rushiliu naturalcarbonnanodotstoxicityassessmentandtheranosticbiologicalapplication AT michaelhsiao naturalcarbonnanodotstoxicityassessmentandtheranosticbiologicalapplication
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Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

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