Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

The antibiotics trimethoprim (TMP) and sulfamethoxazole (SMX) synergistically inhibit bacterial tetrahydrofolate biosynthesis, apparently because SMX potentiates TMP activity. Here, Minato et al. identify a metabolic feedback loop in this pathway, revealing that TMP also potentiates SMX activity.

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Autores principales:	Yusuke Minato, Surendra Dawadi, Shannon L. Kordus, Abiram Sivanandam, Courtney C. Aldrich, Anthony D. Baughn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/693c54c67db3481ba3a9bc7c7cdf3759
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spelling	oai:doaj.org-article:693c54c67db3481ba3a9bc7c7cdf37592021-12-02T16:56:42ZMutual potentiation drives synergy between trimethoprim and sulfamethoxazole10.1038/s41467-018-03447-x2041-1723https://doaj.org/article/693c54c67db3481ba3a9bc7c7cdf37592018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03447-xhttps://doaj.org/toc/2041-1723The antibiotics trimethoprim (TMP) and sulfamethoxazole (SMX) synergistically inhibit bacterial tetrahydrofolate biosynthesis, apparently because SMX potentiates TMP activity. Here, Minato et al. identify a metabolic feedback loop in this pathway, revealing that TMP also potentiates SMX activity.Yusuke MinatoSurendra DawadiShannon L. KordusAbiram SivanandamCourtney C. AldrichAnthony D. BaughnNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Minato Surendra Dawadi Shannon L. Kordus Abiram Sivanandam Courtney C. Aldrich Anthony D. Baughn Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole
description	The antibiotics trimethoprim (TMP) and sulfamethoxazole (SMX) synergistically inhibit bacterial tetrahydrofolate biosynthesis, apparently because SMX potentiates TMP activity. Here, Minato et al. identify a metabolic feedback loop in this pathway, revealing that TMP also potentiates SMX activity.
format	article
author	Yusuke Minato Surendra Dawadi Shannon L. Kordus Abiram Sivanandam Courtney C. Aldrich Anthony D. Baughn
author_facet	Yusuke Minato Surendra Dawadi Shannon L. Kordus Abiram Sivanandam Courtney C. Aldrich Anthony D. Baughn
author_sort	Yusuke Minato
title	Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole
title_short	Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole
title_full	Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole
title_fullStr	Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole
title_full_unstemmed	Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole
title_sort	mutual potentiation drives synergy between trimethoprim and sulfamethoxazole
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/693c54c67db3481ba3a9bc7c7cdf3759
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_version_	1718382742562930688

Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

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