Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.

Aging and gender have a strong influence on the functional capacity of the immune system. In general, the immune response in females is stronger than that in males, but there is scant information about the effect of aging on the gender difference in the immune response. To address this question, we...

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Autores principales:	Saara Marttila, Juulia Jylhävä, Tapio Nevalainen, Matti Nykter, Marja Jylhä, Antti Hervonen, Liina Tserel, Pärt Peterson, Mikko Hurme
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/693fdeff98ac4ef0b41e8e0e404066db
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spelling	oai:doaj.org-article:693fdeff98ac4ef0b41e8e0e404066db2021-11-18T07:42:14ZTranscriptional analysis reveals gender-specific changes in the aging of the human immune system.1932-620310.1371/journal.pone.0066229https://doaj.org/article/693fdeff98ac4ef0b41e8e0e404066db2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776639/?tool=EBIhttps://doaj.org/toc/1932-6203Aging and gender have a strong influence on the functional capacity of the immune system. In general, the immune response in females is stronger than that in males, but there is scant information about the effect of aging on the gender difference in the immune response. To address this question, we performed a transcriptomic analysis of peripheral blood mononuclear cells derived from elderly individuals (nonagenarians, n = 146) and young controls (aged 19-30 years, n = 30). When compared to young controls, we found 339 and 248 genes that were differentially expressed (p<0.05, fold change >1.5 or <-1.5) in nonagenarian females and males, respectively, 180 of these genes were changed in both genders. An analysis of the affected signaling pathways revealed a clear gender bias: there were 48 pathways that were significantly changed in females, while only 29 were changed in males. There were 24 pathways that were shared between both genders. Our results indicate that female nonagenarians have weaker T cell defenses and a more prominent pro-inflammatory response as compared to males. In males significantly fewer pathways were affected, two of which are known to be regulated by estrogen. These data show that the effects of aging on the human immune system are significantly different in males and females.Saara MarttilaJuulia JylhäväTapio NevalainenMatti NykterMarja JylhäAntti HervonenLiina TserelPärt PetersonMikko HurmePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66229 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saara Marttila Juulia Jylhävä Tapio Nevalainen Matti Nykter Marja Jylhä Antti Hervonen Liina Tserel Pärt Peterson Mikko Hurme Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
description	Aging and gender have a strong influence on the functional capacity of the immune system. In general, the immune response in females is stronger than that in males, but there is scant information about the effect of aging on the gender difference in the immune response. To address this question, we performed a transcriptomic analysis of peripheral blood mononuclear cells derived from elderly individuals (nonagenarians, n = 146) and young controls (aged 19-30 years, n = 30). When compared to young controls, we found 339 and 248 genes that were differentially expressed (p<0.05, fold change >1.5 or <-1.5) in nonagenarian females and males, respectively, 180 of these genes were changed in both genders. An analysis of the affected signaling pathways revealed a clear gender bias: there were 48 pathways that were significantly changed in females, while only 29 were changed in males. There were 24 pathways that were shared between both genders. Our results indicate that female nonagenarians have weaker T cell defenses and a more prominent pro-inflammatory response as compared to males. In males significantly fewer pathways were affected, two of which are known to be regulated by estrogen. These data show that the effects of aging on the human immune system are significantly different in males and females.
format	article
author	Saara Marttila Juulia Jylhävä Tapio Nevalainen Matti Nykter Marja Jylhä Antti Hervonen Liina Tserel Pärt Peterson Mikko Hurme
author_facet	Saara Marttila Juulia Jylhävä Tapio Nevalainen Matti Nykter Marja Jylhä Antti Hervonen Liina Tserel Pärt Peterson Mikko Hurme
author_sort	Saara Marttila
title	Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
title_short	Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
title_full	Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
title_fullStr	Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
title_full_unstemmed	Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
title_sort	transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/693fdeff98ac4ef0b41e8e0e404066db
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Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.

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