Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots

The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/Zn...

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Autores principales:	Vuyelwa Ncapayi, Neethu Ninan, Thabang C. Lebepe, Sundararajan Parani, Aswathy Ravindran Girija, Richard Bright, Krasimir Vasilev, Rodney Maluleke, Ncediwe Tsolekile, Tetsuya Kodama, Oluwatobi S. Oluwafemi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	near infra-red quantum dots bioimaging prostate cancer Gram-positive bacteria Gram-negative bacteria Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/69447d3c27c04eb1ae628ce32be2da5b
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spelling	oai:doaj.org-article:69447d3c27c04eb1ae628ce32be2da5b2021-11-25T17:57:24ZDiagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots10.3390/ijms2222125141422-00671661-6596https://doaj.org/article/69447d3c27c04eb1ae628ce32be2da5b2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12514https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in <i>Staphylococcus aureus</i>, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.Vuyelwa NcapayiNeethu NinanThabang C. LebepeSundararajan ParaniAswathy Ravindran GirijaRichard BrightKrasimir VasilevRodney MalulekeNcediwe TsolekileTetsuya KodamaOluwatobi S. OluwafemiMDPI AGarticlenear infra-red quantum dotsbioimagingprostate cancerGram-positive bacteriaGram-negative bacteriaBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12514, p 12514 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	near infra-red quantum dots bioimaging prostate cancer Gram-positive bacteria Gram-negative bacteria Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	near infra-red quantum dots bioimaging prostate cancer Gram-positive bacteria Gram-negative bacteria Biology (General) QH301-705.5 Chemistry QD1-999 Vuyelwa Ncapayi Neethu Ninan Thabang C. Lebepe Sundararajan Parani Aswathy Ravindran Girija Richard Bright Krasimir Vasilev Rodney Maluleke Ncediwe Tsolekile Tetsuya Kodama Oluwatobi S. Oluwafemi Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
description	The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in <i>Staphylococcus aureus</i>, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.
format	article
author	Vuyelwa Ncapayi Neethu Ninan Thabang C. Lebepe Sundararajan Parani Aswathy Ravindran Girija Richard Bright Krasimir Vasilev Rodney Maluleke Ncediwe Tsolekile Tetsuya Kodama Oluwatobi S. Oluwafemi
author_facet	Vuyelwa Ncapayi Neethu Ninan Thabang C. Lebepe Sundararajan Parani Aswathy Ravindran Girija Richard Bright Krasimir Vasilev Rodney Maluleke Ncediwe Tsolekile Tetsuya Kodama Oluwatobi S. Oluwafemi
author_sort	Vuyelwa Ncapayi
title	Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_short	Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_full	Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_fullStr	Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_full_unstemmed	Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_sort	diagnosis of prostate cancer and prostatitis using near infra-red fluorescent aginse/zns quantum dots
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/69447d3c27c04eb1ae628ce32be2da5b
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Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots

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