Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation

Abstract Long natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming m...

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Autores principales:	Sergei Korneev, Jekaterina Garaliene, Gabriella Taylor, Ildikó Kemenes, György Kemenes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6947b1ffac4c4eef82a7326db6b60f78
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spelling	oai:doaj.org-article:6947b1ffac4c4eef82a7326db6b60f782021-12-02T14:11:32ZTime dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation10.1038/s41598-021-83190-42045-2322https://doaj.org/article/6947b1ffac4c4eef82a7326db6b60f782021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83190-4https://doaj.org/toc/2045-2322Abstract Long natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming majority of long NATs remain unclear. Here we report on the characterization of a novel molluscan nitric oxide synthase (NOS)-related long non-coding NAT (Lym-NOS1AS). This NAT is spliced and polyadenylated and is transcribed from the non-template strand of the Lym-NOS1 gene. We demonstrate that the Lym-NOS1AS is co-expressed with the sense Lym-NOS1 mRNA in a key neuron of memory network. Also, we report that the Lym-NOS1AS is temporally and spatially regulated by one-trial conditioning leading to long term memory (LTM) formation. Specifically, in the cerebral, but not in the buccal ganglia, the temporal pattern of changes in Lym-NOS1AS expression after training correlates with the alteration of memory lapse and non-lapse periods. Our data suggest that the Lym-NOS1AS plays a role in the consolidation of nitric oxide-dependent LTM.Sergei KorneevJekaterina GaralieneGabriella TaylorIldikó KemenesGyörgy KemenesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sergei Korneev Jekaterina Garaliene Gabriella Taylor Ildikó Kemenes György Kemenes Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation
description	Abstract Long natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming majority of long NATs remain unclear. Here we report on the characterization of a novel molluscan nitric oxide synthase (NOS)-related long non-coding NAT (Lym-NOS1AS). This NAT is spliced and polyadenylated and is transcribed from the non-template strand of the Lym-NOS1 gene. We demonstrate that the Lym-NOS1AS is co-expressed with the sense Lym-NOS1 mRNA in a key neuron of memory network. Also, we report that the Lym-NOS1AS is temporally and spatially regulated by one-trial conditioning leading to long term memory (LTM) formation. Specifically, in the cerebral, but not in the buccal ganglia, the temporal pattern of changes in Lym-NOS1AS expression after training correlates with the alteration of memory lapse and non-lapse periods. Our data suggest that the Lym-NOS1AS plays a role in the consolidation of nitric oxide-dependent LTM.
format	article
author	Sergei Korneev Jekaterina Garaliene Gabriella Taylor Ildikó Kemenes György Kemenes
author_facet	Sergei Korneev Jekaterina Garaliene Gabriella Taylor Ildikó Kemenes György Kemenes
author_sort	Sergei Korneev
title	Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation
title_short	Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation
title_full	Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation
title_fullStr	Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation
title_full_unstemmed	Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation
title_sort	time dependent differential regulation of a novel long non-coding natural antisense rna during long-term memory formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6947b1ffac4c4eef82a7326db6b60f78
work_keys_str_mv	AT sergeikorneev timedependentdifferentialregulationofanovellongnoncodingnaturalantisensernaduringlongtermmemoryformation AT jekaterinagaraliene timedependentdifferentialregulationofanovellongnoncodingnaturalantisensernaduringlongtermmemoryformation AT gabriellataylor timedependentdifferentialregulationofanovellongnoncodingnaturalantisensernaduringlongtermmemoryformation AT ildikokemenes timedependentdifferentialregulationofanovellongnoncodingnaturalantisensernaduringlongtermmemoryformation AT gyorgykemenes timedependentdifferentialregulationofanovellongnoncodingnaturalantisensernaduringlongtermmemoryformation
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Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation

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