Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation

Limited information on residue depletion of doxycycline (DC) is available in yellow catfish (<i>Pelteobagrus fulvidraco</i>) using the determination of LC-MS/MS based upon a rapid and simple method of sample preparation. This study collected plasma and tissue samples of yellow catfish at...

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Autores principales:	Ning Xu, Bo Cheng, Miao Li, Zhoumeng Lin, Xiaohui Ai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	doxycycline LC-MS/MS QuEChERs withdrawal time yellow catfish Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/694bbf6df286442d8b5fca5ce3dbafea
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spelling	oai:doaj.org-article:694bbf6df286442d8b5fca5ce3dbafea2021-11-25T17:32:33ZWithdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation10.3390/foods101125542304-8158https://doaj.org/article/694bbf6df286442d8b5fca5ce3dbafea2021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2554https://doaj.org/toc/2304-8158Limited information on residue depletion of doxycycline (DC) is available in yellow catfish (<i>Pelteobagrus fulvidraco</i>) using the determination of LC-MS/MS based upon a rapid and simple method of sample preparation. This study collected plasma and tissue samples of yellow catfish at pre-determined time points following 3-day consecutive oral administration of DC at 20 mg/kg. The samples were prepared using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) approach. The limit of detection and the limit of quantitation were 2.5 and 5 µg/kg or µg/L, respectively, for DC in plasma and tissues (e.g., muscle + skin, liver, kidney, and gill). The recoveries of DC ranged from 67.2% to 86.2%. The decision limit (CCα) and the detection capability (CCβ) were from 106.2 to 127.8 μg/kg or μg/L. The withdrawal times of DC in muscle + skin were estimated to be 22 d based on the guidelines in China and Europe and 27 d based on Japan’s standard. Overall, this study not only provides an efficient method to rapidly determine the DC concentrations in fish-derived tissues but also provides important information on the safety assessment of DC in aquatic animal-derived food products.Ning XuBo ChengMiao LiZhoumeng LinXiaohui AiMDPI AGarticledoxycyclineLC-MS/MSQuEChERswithdrawal timeyellow catfishChemical technologyTP1-1185ENFoods, Vol 10, Iss 2554, p 2554 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	doxycycline LC-MS/MS QuEChERs withdrawal time yellow catfish Chemical technology TP1-1185
spellingShingle	doxycycline LC-MS/MS QuEChERs withdrawal time yellow catfish Chemical technology TP1-1185 Ning Xu Bo Cheng Miao Li Zhoumeng Lin Xiaohui Ai Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation
description	Limited information on residue depletion of doxycycline (DC) is available in yellow catfish (<i>Pelteobagrus fulvidraco</i>) using the determination of LC-MS/MS based upon a rapid and simple method of sample preparation. This study collected plasma and tissue samples of yellow catfish at pre-determined time points following 3-day consecutive oral administration of DC at 20 mg/kg. The samples were prepared using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) approach. The limit of detection and the limit of quantitation were 2.5 and 5 µg/kg or µg/L, respectively, for DC in plasma and tissues (e.g., muscle + skin, liver, kidney, and gill). The recoveries of DC ranged from 67.2% to 86.2%. The decision limit (CCα) and the detection capability (CCβ) were from 106.2 to 127.8 μg/kg or μg/L. The withdrawal times of DC in muscle + skin were estimated to be 22 d based on the guidelines in China and Europe and 27 d based on Japan’s standard. Overall, this study not only provides an efficient method to rapidly determine the DC concentrations in fish-derived tissues but also provides important information on the safety assessment of DC in aquatic animal-derived food products.
format	article
author	Ning Xu Bo Cheng Miao Li Zhoumeng Lin Xiaohui Ai
author_facet	Ning Xu Bo Cheng Miao Li Zhoumeng Lin Xiaohui Ai
author_sort	Ning Xu
title	Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation
title_short	Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation
title_full	Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation
title_fullStr	Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation
title_full_unstemmed	Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation
title_sort	withdrawal interval estimation of doxycycline in yellow catfish (<i>pelteobagrus fulvidraco</i>) using an lc-ms/ms method based upon quechers sampling preparation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/694bbf6df286442d8b5fca5ce3dbafea
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Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation

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