Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.

The cytoskeleton of living cells contains many types of crosslinkers. Some crosslinkers allow energy-free rotations between filaments and others do not. The mechanical interplay between these different crosslinkers is an open issue in cytoskeletal mechanics. Therefore, we develop a theoretical frame...

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Autores principales:	Moumita Das, D A Quint, J M Schwarz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69501c83c008467c8360c09097b53be8
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spelling	oai:doaj.org-article:69501c83c008467c8360c09097b53be82021-11-18T07:19:22ZRedundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.1932-620310.1371/journal.pone.0035939https://doaj.org/article/69501c83c008467c8360c09097b53be82012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22590515/?tool=EBIhttps://doaj.org/toc/1932-6203The cytoskeleton of living cells contains many types of crosslinkers. Some crosslinkers allow energy-free rotations between filaments and others do not. The mechanical interplay between these different crosslinkers is an open issue in cytoskeletal mechanics. Therefore, we develop a theoretical framework based on rigidity percolation to study a generic filamentous system containing both stretching and bond-bending forces to address this issue. The framework involves both analytical calculations via effective medium theory and numerical simulations on a percolating triangular lattice with very good agreement between both. We find that the introduction of angle-constraining crosslinkers to a semiflexible filamentous network with freely rotating crosslinks can cooperatively lower the onset of rigidity to the connectivity percolation threshold-a result argued for years but never before obtained via effective medium theory. This allows the system to ultimately attain rigidity at the lowest concentration of material possible. We further demonstrate that introducing angle-constraining crosslinks results in mechanical behaviour similar to just freely rotating crosslinked semflexible filaments, indicating redundancy and universality. Our results also impact upon collagen and fibrin networks in biological and bio-engineered tissues.Moumita DasD A QuintJ M SchwarzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e35939 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moumita Das D A Quint J M Schwarz Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.
description	The cytoskeleton of living cells contains many types of crosslinkers. Some crosslinkers allow energy-free rotations between filaments and others do not. The mechanical interplay between these different crosslinkers is an open issue in cytoskeletal mechanics. Therefore, we develop a theoretical framework based on rigidity percolation to study a generic filamentous system containing both stretching and bond-bending forces to address this issue. The framework involves both analytical calculations via effective medium theory and numerical simulations on a percolating triangular lattice with very good agreement between both. We find that the introduction of angle-constraining crosslinkers to a semiflexible filamentous network with freely rotating crosslinks can cooperatively lower the onset of rigidity to the connectivity percolation threshold-a result argued for years but never before obtained via effective medium theory. This allows the system to ultimately attain rigidity at the lowest concentration of material possible. We further demonstrate that introducing angle-constraining crosslinks results in mechanical behaviour similar to just freely rotating crosslinked semflexible filaments, indicating redundancy and universality. Our results also impact upon collagen and fibrin networks in biological and bio-engineered tissues.
format	article
author	Moumita Das D A Quint J M Schwarz
author_facet	Moumita Das D A Quint J M Schwarz
author_sort	Moumita Das
title	Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.
title_short	Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.
title_full	Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.
title_fullStr	Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.
title_full_unstemmed	Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.
title_sort	redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/69501c83c008467c8360c09097b53be8
work_keys_str_mv	AT moumitadas redundancyandcooperativityinthemechanicsofcompositelycrosslinkedfilamentousnetworks AT daquint redundancyandcooperativityinthemechanicsofcompositelycrosslinkedfilamentousnetworks AT jmschwarz redundancyandcooperativityinthemechanicsofcompositelycrosslinkedfilamentousnetworks
_version_	1718423602067406848

Redundancy and cooperativity in the mechanics of compositely crosslinked filamentous networks.

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