Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent β-arrestin2 pathways.

Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent β-arrestin2 pathways.

Angiotensin II (AngII) type 1 receptor (AT1-R) can be activated by mechanical stress (MS) without the involvement of AngII during the development of cardiomyocyte hypertrophy, in which G protein-independent pathways are critically involved. Although β-arrestin2-biased signaling has been speculated,...

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Bibliographic Details
Main Authors: Shijun Wang, Hui Gong, Guoliang Jiang, Yong Ye, Jian Wu, Jieyun You, Guoping Zhang, Aijun Sun, Issei Komuro, Junbo Ge, Yunzeng Zou
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/6951044e5e7c4b33be1b416ee4506f14
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