ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS

Abstract. The review article presents data concerning pathogenetic mechanisms of acute pancreatitis development and poly-organ insufficiency. It was shown IL-1 is among important factors that may determine a severity degree of pancreatitis. Production of this cytokine provides clinical features of a...

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Autores principales:	A. N. Plekhanov, D. I. Reshetnikov, A. I. Tovarshinov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	acute pancreatitis pathogenesis il-1 peroxidation products Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/695816b7a97d4291b41df52cdba2fcf2
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spelling	oai:doaj.org-article:695816b7a97d4291b41df52cdba2fcf22021-11-18T08:03:39ZROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS1563-06252313-741X10.15789/1563-0625-2009-2-3-141-146https://doaj.org/article/695816b7a97d4291b41df52cdba2fcf22014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/274https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The review article presents data concerning pathogenetic mechanisms of acute pancreatitis development and poly-organ insufficiency. It was shown IL-1 is among important factors that may determine a severity degree of pancreatitis. Production of this cytokine provides clinical features of acute pancreatitis, as well as direct cytotoxic effect upon tumor cells. The article also deals with intensified lipid superoxide generation caused by IL-1. Upon development of inflammatory events, interactions between free radicals and membrane lipids provide synthesis of superoxide compounds that display distinct chemotactic activity towards phagocytes and other immunocompetent cells.A. N. PlekhanovD. I. ReshetnikovA. I. TovarshinovSPb RAACIarticleacute pancreatitispathogenesisil-1peroxidation productsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 141-146 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	acute pancreatitis pathogenesis il-1 peroxidation products Immunologic diseases. Allergy RC581-607
spellingShingle	acute pancreatitis pathogenesis il-1 peroxidation products Immunologic diseases. Allergy RC581-607 A. N. Plekhanov D. I. Reshetnikov A. I. Tovarshinov ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
description	Abstract. The review article presents data concerning pathogenetic mechanisms of acute pancreatitis development and poly-organ insufficiency. It was shown IL-1 is among important factors that may determine a severity degree of pancreatitis. Production of this cytokine provides clinical features of acute pancreatitis, as well as direct cytotoxic effect upon tumor cells. The article also deals with intensified lipid superoxide generation caused by IL-1. Upon development of inflammatory events, interactions between free radicals and membrane lipids provide synthesis of superoxide compounds that display distinct chemotactic activity towards phagocytes and other immunocompetent cells.
format	article
author	A. N. Plekhanov D. I. Reshetnikov A. I. Tovarshinov
author_facet	A. N. Plekhanov D. I. Reshetnikov A. I. Tovarshinov
author_sort	A. N. Plekhanov
title	ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_short	ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_full	ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_fullStr	ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_full_unstemmed	ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_sort	role of il-1 and lipid peroxidation products in pathogenesis of acute pancreatitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/695816b7a97d4291b41df52cdba2fcf2
work_keys_str_mv	AT anplekhanov roleofil1andlipidperoxidationproductsinpathogenesisofacutepancreatitis AT direshetnikov roleofil1andlipidperoxidationproductsinpathogenesisofacutepancreatitis AT aitovarshinov roleofil1andlipidperoxidationproductsinpathogenesisofacutepancreatitis
_version_	1718422548710948864

ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS

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